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1
Nucleotide sequences of mRNAs encoding Epstein-Barr virus nuclear proteins: a probable transcriptional initiation site.编码爱泼斯坦-巴尔病毒核蛋白的信使核糖核酸的核苷酸序列：一个可能的转录起始位点。
Proc Natl Acad Sci U S A. 1986 Jul;83(14):5096-100. doi: 10.1073/pnas.83.14.5096.
2
Analysis of the transcript encoding the latent Epstein-Barr virus nuclear antigen I: a potentially polycistronic message generated by long-range splicing of several exons.编码潜伏性爱泼斯坦-巴尔病毒核抗原I的转录本分析：由多个外显子的长距离剪接产生的一个潜在多顺反子信息。
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8305-9. doi: 10.1073/pnas.82.24.8305.
3
Identification of sequences in Epstein-Barr virus DNA required for the expression of the second Epstein-Barr virus-determined nuclear antigen in COS-1 cells.确定在COS-1细胞中表达第二种爱泼斯坦-巴尔病毒核抗原所需的爱泼斯坦-巴尔病毒DNA序列。
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U2 region of Epstein-Barr virus DNA may encode Epstein-Barr nuclear antigen 2.爱泼斯坦－巴尔病毒DNA的U2区域可能编码爱泼斯坦－巴尔核抗原2。
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One of two Epstein-Barr virus nuclear antigens contains a glycine-alanine copolymer domain.两种爱泼斯坦-巴尔病毒核抗原之一含有一个甘氨酸-丙氨酸共聚结构域。
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A bicistronic Epstein-Barr virus mRNA encodes two nuclear proteins in latently infected, growth-transformed lymphocytes.一个双顺反子的爱泼斯坦-巴尔病毒信使核糖核酸在潜伏感染、生长转化的淋巴细胞中编码两种核蛋白。
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Latent and viral replicative transcription in vivo from the BamHI K fragment of Epstein-Barr virus DNA.爱泼斯坦-巴尔病毒DNA的BamHI K片段在体内的潜伏性和病毒复制性转录
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Domains of the Epstein-Barr virus nuclear antigen 2 (EBNA2) involved in the transactivation of the latent membrane protein 1 and the EBNA Cp promoters.爱泼斯坦-巴尔病毒核抗原2（EBNA2）参与潜伏膜蛋白1和EBNA Cp启动子反式激活的结构域。
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Viral and cellular factors influence the activity of the Epstein-Barr virus BCR2 and BWR1 promoters in cells of different phenotype.病毒和细胞因子影响爱泼斯坦-巴尔病毒BCR2和BWR1启动子在不同表型细胞中的活性。
Virology. 1993 Apr;193(2):774-85. doi: 10.1006/viro.1993.1186.
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Epstein-Barr virus-encoded nuclear antigen 2 activates the viral latent membrane protein promoter by modulating the activity of a negative regulatory element.爱泼斯坦-巴尔病毒编码的核抗原2通过调节一个负调控元件的活性来激活病毒潜伏膜蛋白启动子。
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New Interactors of the Truncated EBNA-LP Protein Identified by Mass Spectrometry in P3HR1 Burkitt's Lymphoma Cells.通过质谱法在P3HR1伯基特淋巴瘤细胞中鉴定出截短型EBNA-LP蛋白的新相互作用分子。
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Epstein-Barr virus nuclear antigen 3A promotes cellular proliferation by repression of the cyclin-dependent kinase inhibitor p21WAF1/CIP1.爱泼斯坦-巴尔病毒核抗原3A通过抑制细胞周期蛋白依赖性激酶抑制剂p21WAF1/CIP1来促进细胞增殖。
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10
Epstein-Barr virus BamHI W repeat number limits EBNA2/EBNA-LP coexpression in newly infected B cells and the efficiency of B-cell transformation: a rationale for the multiple W repeats in wild-type virus strains.爱泼斯坦-巴尔病毒 BamHI W 重复数限制新感染 B 细胞中 EBNA2/EBNA-LP 的共表达和 B 细胞转化的效率：野生型病毒株中多个 W 重复的基本原理。
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本文引用的文献

1
Initiation of translation of the cauliflower mosaic virus genome from a polycistronic mRNA: evidence from deletion mutagenesis.花椰菜花叶病毒基因组从多顺反子 mRNA 翻译的起始：缺失突变的证据。
EMBO J. 1984 Dec 1;3(12):2731-6. doi: 10.1002/j.1460-2075.1984.tb02203.x.
2
Striking similarities are exhibited by two small Epstein-Barr virus-encoded ribonucleic acids and the adenovirus-associated ribonucleic acids VAI and VAII.两种小的爱泼斯坦-巴尔病毒编码的核糖核酸与腺病毒相关核糖核酸VAI和VAII表现出惊人的相似性。
Mol Cell Biol. 1981 Sep;1(9):785-96. doi: 10.1128/mcb.1.9.785-796.1981.
3
A catalogue of splice junction sequences.剪接连接序列目录。
Nucleic Acids Res. 1982 Jan 22;10(2):459-72. doi: 10.1093/nar/10.2.459.
4
Studies on the selectivity of DNA precipitation by spermine.精胺对DNA沉淀的选择性研究。
Nucleic Acids Res. 1981 Oct 24;9(20):5493-504. doi: 10.1093/nar/9.20.5493.
5
Adenovirus VAI RNA facilitates the initiation of translation in virus-infected cells.腺病毒VAI RNA促进病毒感染细胞中的翻译起始。
Cell. 1984 May;37(1):291-8. doi: 10.1016/0092-8674(84)90325-8.
6
Initiation of translation at internal AUG codons in mammalian cells.哺乳动物细胞中内部AUG密码子处的翻译起始。
Nature. 1984;309(5963):82-5. doi: 10.1038/309082a0.
7
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.真核生物mRNA翻译起始位点上游序列的汇编与分析。
Nucleic Acids Res. 1984 Jan 25;12(2):857-72. doi: 10.1093/nar/12.2.857.
8
The EB virus genome in Daudi Burkitt's lymphoma cells has a deletion similar to that observed in a non-transforming strain (P3HR-1) of the virus.达乌迪伯基特淋巴瘤细胞中的EB病毒基因组存在一种缺失，类似于在该病毒的非转化株（P3HR-1）中观察到的缺失。
EMBO J. 1984 Apr;3(4):813-21. doi: 10.1002/j.1460-2075.1984.tb01890.x.
9
Identification of Epstein-Barr nuclear antigen polypeptide in mouse and monkey cells after gene transfer with a cloned 2.9-kilobase-pair subfragment of the genome.用基因组中一个克隆的2.9千碱基对的亚片段进行基因转移后，在小鼠和猴细胞中鉴定爱泼斯坦-巴尔核抗原多肽。
Proc Natl Acad Sci U S A. 1984 Jan;81(1):43-7. doi: 10.1073/pnas.81.1.43.
10
One of two Epstein-Barr virus nuclear antigens contains a glycine-alanine copolymer domain.两种爱泼斯坦-巴尔病毒核抗原之一含有一个甘氨酸-丙氨酸共聚结构域。
Proc Natl Acad Sci U S A. 1983 Sep;80(18):5665-9. doi: 10.1073/pnas.80.18.5665.

编码爱泼斯坦-巴尔病毒核蛋白的信使核糖核酸的核苷酸序列：一个可能的转录起始位点。

Nucleotide sequences of mRNAs encoding Epstein-Barr virus nuclear proteins: a probable transcriptional initiation site.

作者信息

Sample J, Hummel M, Braun D, Birkenbach M, Kieff E

出版信息

Proc Natl Acad Sci U S A. 1986 Jul;83(14):5096-100. doi: 10.1073/pnas.83.14.5096.

DOI:10.1073/pnas.83.14.5096
PMID:3460083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC323897/
Abstract

Three cDNA clones of the second Epstein-Barr virus nuclear antigen (EBNA2) mRNA and two of the EBNA1 mRNA were analyzed. Two EBNA2 clones begin 42 bases 3' to a promoter in the Epstein-Barr virus long internal repeat, which is likely to be the EBNA2 promoter. Surprisingly, the first splice creates an AUG at the beginning of the first of two nonoverlapping open reading frames. The second open reading frame encodes EBNA2. Two incomplete EBNA1 mRNA cDNA clones begin with parts of two of the EBNA2 exons and contain two other exons that map 19 and 59 kilobases 3' to the EBNA2 coding domain. The 3' exon of this mRNA encodes EBNA1. A model for regulation of transcription of these RNAs is presented.

摘要

对第二个爱泼斯坦-巴尔病毒核抗原（EBNA2）mRNA的三个cDNA克隆和EBNA1 mRNA的两个cDNA克隆进行了分析。两个EBNA2克隆在爱泼斯坦-巴尔病毒长内部重复序列中一个启动子的3'端42个碱基处开始，这可能是EBNA2启动子。令人惊讶的是，第一次剪接在两个不重叠的开放阅读框中第一个的开头产生了一个AUG。第二个开放阅读框编码EBNA2。两个不完整的EBNA1 mRNA cDNA克隆以EBNA2的两个外显子的部分开头，并包含另外两个外显子，它们位于EBNA2编码域3'端19和59千碱基处。该mRNA的3'外显子编码EBNA1。提出了这些RNA转录调控的模型。