Zola H, Fusco M, Macardle P J, Flego L, Roberton D
Child Health Research Institute, Adelaide, Australia.
Pediatr Res. 1995 Sep;38(3):397-403. doi: 10.1203/00006450-199509000-00021.
The expression of receptors for several cytokines (IL 2, IL-4, IL-6, IL-7, tumor necrosis factor, and interferon-gamma) was examined in human cord blood cells in comparison with adult blood cells. A previously described high sensitivity immunofluorescence procedure was used to render the low levels of receptor measurable. Cord blood lymphocytes expressed measurable levels of most cytokine receptors, but expression tended to be lower than in adult blood cells. Examination of different lymphocyte subpopulations revealed a complex pattern with some cell types expressing particular receptors equivalent to adult levels. Cord and adult blood monocytes expressed similar cytokine receptor profiles. Receptor expression in cord lymphocytes could be regulated by activation. The results provide indications as to the relative activities of different cytokines in the development of the immune system in the neonate.
与成人血细胞相比，研究了几种细胞因子（白细胞介素2、白细胞介素4、白细胞介素6、白细胞介素7、肿瘤坏死因子和干扰素-γ）受体在人脐血细胞中的表达情况。采用先前描述的高灵敏度免疫荧光程序来检测低水平的受体。脐血淋巴细胞表达了大多数细胞因子受体的可测量水平，但表达水平往往低于成人血细胞。对不同淋巴细胞亚群的检测揭示了一种复杂的模式，一些细胞类型表达的特定受体水平与成人相当。脐血和成人血单核细胞表达相似的细胞因子受体谱。脐血淋巴细胞中的受体表达可通过激活来调节。这些结果为新生儿免疫系统发育中不同细胞因子的相对活性提供了线索。
