白细胞介素-12和γ干扰素。它们总是相伴出现吗？ - Suppr

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超能文献

Interleukin-12 and interferon-gamma. Do they always go together?

作者信息

Trinchieri G

机构信息

Wistar Institute, Philadelphia, Pennsylvania, USA.

出版信息

Am J Pathol. 1995 Dec;147(6):1534-8.

PMID:7495276

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1869958/

Abstract

摘要

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Interleukin-12 and interferon-gamma. Do they always go together?白细胞介素-12和γ干扰素。它们总是相伴出现吗？

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本文引用的文献

Interleukin-12 and its role in the generation of TH1 cells.白细胞介素-12及其在TH1细胞生成中的作用。

Immunol Today. 1993 Jul;14(7):335-8. doi: 10.1016/0167-5699(93)90230-I.

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.皮肤利什曼病的消退：白细胞介素12引发保护性1型辅助性T细胞免疫反应。

J Exp Med. 1993 Jun 1;177(6):1797-802. doi: 10.1084/jem.177.6.1797.

Recombinant interleukin 12 cures mice infected with Leishmania major.重组白细胞介素12可治愈感染硕大利什曼原虫的小鼠。

J Exp Med. 1993 May 1;177(5):1505-9. doi: 10.1084/jem.177.5.1505.

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.自然杀伤细胞刺激因子（白细胞介素12 [IL-12]）诱导1型辅助性T细胞（Th1）特异性免疫反应，并抑制产生IL-4的Th细胞的发育。

J Exp Med. 1993 Apr 1;177(4):1199-204. doi: 10.1084/jem.177.4.1199.

Multiple effects on peripheral hematology following administration of recombinant human interleukin 12 to nonhuman primates.

Biochem Biophys Res Commun. 1994 Nov 15;204(3):1150-7. doi: 10.1006/bbrc.1994.2583.

IL-12 protects bone marrow from and sensitizes intestinal tract to ionizing radiation.白细胞介素-12可保护骨髓免受电离辐射，并使肠道对电离辐射敏感。

J Immunol. 1994 Nov 1;153(9):4230-7.

Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon.白细胞介素12在内毒素血症期间于体内产生，并刺激γ干扰素的合成。

Infect Immun. 1994 Oct;62(10):4244-9. doi: 10.1128/iai.62.10.4244-4249.1994.

Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction.白细胞介素12、γ干扰素和肿瘤坏死因子α是全身性施瓦茨曼反应的关键细胞因子。

J Exp Med. 1994 Sep 1;180(3):907-15. doi: 10.1084/jem.180.3.907.

T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-gamma and is inhibited by transforming growth factor-beta.初始CD4+ T细胞向1型辅助性T细胞的分化需要白细胞介素-12和干扰素-γ的协同作用，并受到转化生长因子-β的抑制。

Eur J Immunol. 1994 Apr;24(4):793-8. doi: 10.1002/eji.1830240403.

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo.给正常小鼠注射重组白细胞介素-12可增强细胞溶解性淋巴细胞活性，并在体内诱导γ-干扰素的产生。

Int Immunol. 1994 Jan;6(1):157-67. doi: 10.1093/intimm/6.1.157.

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