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The short-chain fatty acid butyrate induces apoptosis in colorectal tumour cell lines.

作者信息

Hague A, Paraskeva C

机构信息

Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, UK.

出版信息

Eur J Cancer Prev. 1995 Oct;4(5):359-64. doi: 10.1097/00008469-199510000-00005.

DOI:10.1097/00008469-199510000-00005
PMID:7496324
Abstract
摘要

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bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis.bcl-2和bak可能在丁酸钠诱导的结肠上皮细胞凋亡中起关键作用;然而,bcl-2的过表达并不能防止bak介导的凋亡。
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Bcl-2 deregulation leads to inhibition of sodium butyrate-induced apoptosis in human colorectal carcinoma cells.Bcl-2失调导致人结肠癌细胞中丁酸钠诱导的细胞凋亡受到抑制。
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Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis.胆汁酸可降低丁酸钠对人结肠腺瘤(AA/C1)细胞的凋亡诱导作用:对结肠癌发生的影响。
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Deoxycholic acid and SCFA-induced apoptosis in the human tumor cell-line HT-29 and possible mechanisms.脱氧胆酸和短链脂肪酸诱导人肿瘤细胞系HT-29凋亡及其可能机制。
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Phorbol ester augments butyrate-induced apoptosis of colon cancer cells.
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