Cespuglio R, Marinesco S, Baubet V, Bonnet C, el Kafi B
Département de Médecine Expérimentale, INSERM U52, CNRS URA-1195, Claude Bernard Univ., Lyon, France.
Adv Neuroimmunol. 1995;5(2):145-54. doi: 10.1016/0960-5428(95)00005-m.
In the present review the data supporting the existence at the central level of a stress-sleep relation are reported and discussed. An immobilization stress of 1 or 2 hour(s) is accompanied by a marked polygraphic waking and followed by a significant sleep rebound concerning mainly paradoxical sleep (PS). During the restraint, an important release of 5-hydroxyindoles [5-OHles, a good index of serotonin (5-HT) release] occurs in the basal hypothalamus (BH). This release, produced by the nerve endings originating from the nucleus raphe dorsalis (nRD), might secondarily influence the release and/or the synthesis of hypnogenic substances directly involved in the sleep rebound production. Corticotropin-like intermediate lobe peptide (CLIP, or ACTH18-39) is a peptide possessing hypnogenic properties and derived from proopiomelanocortin (POMC) whose perikarya are contained within the BH (arcuate nucleus). The POMC nerve endings impinge on the nucleus raphe dorsalis, a structure containing sleep permissive components upon which CLIP acts to trigger sleep. It remains to be defined how the activity of the neuronal loop described above is impaired under chronic stress conditions.
在本综述中，我们报告并讨论了支持应激与睡眠关系存在于中枢水平的数据。1或2小时的固定应激会伴随着显著的多导睡眠图觉醒，随后主要是异相睡眠（PS）出现明显的睡眠反弹。在约束期间，基底下丘脑（BH）中会大量释放5-羟吲哚（5-OHles，血清素（5-HT）释放的良好指标）。这种由中缝背核（nRD）的神经末梢产生的释放，可能会继而影响直接参与睡眠反弹产生的催眠物质的释放和/或合成。促肾上腺皮质激素样中叶肽（CLIP，或促肾上腺皮质激素18 - 39）是一种具有催眠特性的肽，它源自阿黑皮素原（POMC），其核周体包含在BH（弓状核）内。POMC神经末梢作用于中缝背核，该结构包含允许睡眠的成分，CLIP作用于这些成分以触发睡眠。在慢性应激条件下，上述神经回路的活动如何受损仍有待确定。
