Ferraro F J, Rush B F, Simonian G T, Bruce C J, Murphy T F, Hsieh J T, Klein K, Condon M
Department of Surgery, University of Medicine and Dentistry of New Jersey/New Jersey Medical School, Newark 07103-2499, USA.
Shock. 1995 Aug;4(2):117-20. doi: 10.1097/00024382-199508000-00007.
We have previously reported superior survival after one level of hemorrhagic shock in germ-free (GF) rats compared with germ-bearing (GB) rats. The objective of this study was to determine the effect of the GF state on survival at different degrees of hemorrhagic shock. GF and GB rats were bled to a mean arterial blood pressure of 30 mmHg. Shock was terminated after 10, 20, 40, or 80% of the maximum shed blood volume was reabsorbed spontaneously. Both shock time and time to decompensation were significantly longer in GF rats (p < .05). Comparative survival was greater for GF rats at most levels of shock (p < .01). This superiority in survival was greatest at moderate shock levels and decreased at severe shock levels. There may be several reasons for the increased tolerance of GF animals to hemorrhagic shock such as metabolic or immunologic variations. It is hard to avoid the fact, however, that the most notable difference between the GF and GB rat is the presence or absence of bacteria.
我们之前曾报道，与有菌（GB）大鼠相比，无菌（GF）大鼠在经历一级失血性休克后具有更高的存活率。本研究的目的是确定GF状态对不同程度失血性休克存活率的影响。将GF和GB大鼠放血至平均动脉血压为30 mmHg。在最大失血量的10%、20%、40%或80%被自发重吸收后终止休克。GF大鼠的休克时间和失代偿时间均显著更长（p < 0.05）。在大多数休克水平下，GF大鼠的相对存活率更高（p < 0.01）。这种存活率优势在中度休克水平时最大，在重度休克水平时降低。GF动物对失血性休克耐受性增加可能有多种原因，如代谢或免疫差异。然而，难以避免的事实是，GF大鼠和GB大鼠之间最显著的差异在于是否存在细菌。
