Nagao Y, Sata M, Tanikawa K, Itoh K, Kameyama T
Department of Oral Surgery, Kurume University School of Medicine, Fukuoka, Japan.
J Oral Pathol Med. 1995 Sep;24(8):354-60. doi: 10.1111/j.1600-0714.1995.tb01199.x.
We have investigated the correlation between the prevalence of hepatitis C virus (HCV), which is detectable in saliva, and oral cancer and other digestive tract cancers in the Northern Kyushu region of Japan. Anti-HCV antibodies were detected in sera from 24 of the 100 patients with oral cancer (24%, p < 0.05 vs the control group, p < 0.01 vs the stomach cancer group), in 11 of 104 patients with non-malignant diseases receiving dental treatment (the control group, 10.6%), and in 12 of 113 patients with stomach cancer (10.6%). HCV-RNA was detected in sera from 17 of 100 oral cancer patients (17%, p < 0.05 vs the control group) and 4 of 104 patients of the control group (3.9%). These results indicate a high prevalence of HCV infection in oral cancer patients, which warrants a systematic study of etiological associations between oral cancer and HCV.
我们调查了日本九州北部地区唾液中可检测到的丙型肝炎病毒（HCV）感染率与口腔癌及其他消化道癌症之间的相关性。在100例口腔癌患者中，有24例（24%）血清中检测到抗HCV抗体（与对照组相比，p<0.05；与胃癌组相比，p<0.01）；在104例接受牙科治疗的非恶性疾病患者（对照组）中，有11例（10.6%）检测到抗HCV抗体；在113例胃癌患者中，有12例（10.6%）检测到抗HCV抗体。在100例口腔癌患者中，有17例（17%）血清中检测到HCV-RNA（与对照组相比，p<0.05），在对照组的104例患者中有4例（3.9%）检测到HCV-RNA。这些结果表明口腔癌患者中HCV感染率较高，这值得对口腔癌与HCV之间的病因学关联进行系统研究。
