van Hoogstraten I M, von Blomberg B M, Boden D, Kraal G, Scheper R J
Department of Pathology, Vrije Universiteit, Amsterdam, The Netherlands.
J Invest Dermatol. 1994 Jan;102(1):80-3. doi: 10.1111/1523-1747.ep12371736.
Oral administration of nickel or chromium to naive guinea pigs results in immune unresponsiveness to subsequent induction of allergic contact hypersensitivity. Such "oral tolerance" depends on the oral dose, is antigen specific, T-suppressor-cell mediated, and very persistent. In contrast, oral antigen administration to sensitized animals results at best in transient desensitization. Here we report that even non-sensitizing epicutaneous skin contacts prevented the subsequent induction of oral tolerance. These data support the view that primed T cells are less sensitive to suppressor T-cell function than naive T cells.
给未接触过镍或铬的豚鼠口服镍或铬会导致其对随后诱导的过敏性接触超敏反应产生免疫无反应性。这种“口服耐受”取决于口服剂量，具有抗原特异性，由T抑制细胞介导，且非常持久。相比之下，给致敏动物口服抗原最多只能导致短暂的脱敏。我们在此报告，即使是非致敏性的经皮皮肤接触也能阻止随后口服耐受的诱导。这些数据支持这样一种观点，即已致敏的T细胞比未接触过抗原的T细胞对抑制性T细胞功能的敏感性更低。
