Konstadoulakis M M, Kroubouzos G, Tosca A, Piperingos G, Marafelia P, Konstadoulakis M, Varelzidis A, Koutras D A
Hippokration Hospital, Dept. of Surgery, Univ. of Athens, Greece.
Thyroidology. 1993 Apr;5(1):1-7.
Thirty four sera from: 12 patients with Systemic Lupus Erythematosus (SLE), 9 with Subacute Cutaneous Lupus Erythematosus (SCLE) and 13 with Discoid Lupus Erythematosus (DLE) (disseminatus 3, localised 10) were tested for the presence of: (a) anti-thyroglobulin and anti-microsomal autoantibodies (b) anti-Sm/RNP, anti-doublestranded. DNA (anti-ds. DNA), anti-single-Stranded. DNA (anti-ss. DNA), anti-cardiolipin (anti-Cl), anti-SSA, anti-SSB, Antinuclear Antibodies (ANA). T3, T4, TSH levels were also determined. Five patients with SLE (41.6%), 4 with SCLE (44.4%), and 2 with DLE (15.3%) had thyroid autoantibodies and only three of the 41 controls (7.3%). Five patients (14.7%), especially from SLE and SCLE groups, had biochemical hypothyroidism whereas only one had hyperthyroidism. Statistical evaluation for the possible coexistence of thyroid autoantibodies with a panel of lupus characteristic autoantibodies, revealed highly significant correlations with anti-Sm/RNP, IgG (p = 0.003) and anti-ds. DNA, IgM (p = 0.012). It may be concluded, that not only SLE but also SCLE predisposes to autoimmune thyroid disease and the prevalence of the latter is related to a great extent to the subset of the LE spectrum. From these results and from the inhibition experiments, it seems that some of the specific mono- or polyclonal autoantibodies may be multiple organ reactive.
对来自以下患者的34份血清进行了检测：12例系统性红斑狼疮（SLE）患者、9例亚急性皮肤型红斑狼疮（SCLE）患者和13例盘状红斑狼疮（DLE）患者（播散性3例，局限性10例），检测项目包括：（a）抗甲状腺球蛋白和抗微粒体自身抗体；（b）抗Sm/RNP、抗双链DNA（抗ds-DNA）、抗单链DNA（抗ss-DNA）、抗心磷脂（抗Cl）、抗SSA、抗SSB、抗核抗体（ANA）。还测定了T3、T4、TSH水平。5例SLE患者（41.6%）、4例SCLE患者（44.4%）和2例DLE患者（15.3%）有甲状腺自身抗体，而41例对照中只有3例（7.3%）有。5例患者（14.7%），尤其是SLE和SCLE组的患者，有生化性甲状腺功能减退，而只有1例有甲状腺功能亢进。对甲状腺自身抗体与一组狼疮特征性自身抗体可能共存的统计学评估显示，与抗Sm/RNP、IgG（p = 0.003）和抗ds-DNA、IgM（p = 0.012）有高度显著相关性。可以得出结论，不仅SLE，而且SCLE都易患自身免疫性甲状腺疾病，后者的患病率在很大程度上与红斑狼疮谱系的亚组有关。从这些结果和抑制实验来看，似乎某些特异性单克隆或多克隆自身抗体可能对多个器官有反应。
