FR901228，一种由紫色色杆菌968号菌株产生的新型抗肿瘤双环缩肽。I. 分类学、发酵、分离、理化及生物学特性以及抗肿瘤活性。
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity.
作者信息
Ueda H, Nakajima H, Hori Y, Fujita T, Nishimura M, Goto T, Okuhara M
机构信息
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
出版信息
J Antibiot (Tokyo). 1994 Mar;47(3):301-10. doi: 10.7164/antibiotics.47.301.
A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as colorless prisms and the molecular formula was determined as C24H36N4O6S2. This antibiotic reverted the transformed morphology of a Ha-ras transformant to normal, and exhibited prominent antitumor activities against murine and human tumor cell lines both in vitro and in vivo.
一种新型抗肿瘤双环缩肽FR901228，从紫色色杆菌968号菌株的发酵液中分离得到，呈无色棱柱体，其分子式确定为C24H36N4O6S2。这种抗生素能使Ha-ras转化体的转化形态恢复正常，并且在体外和体内均对鼠类和人类肿瘤细胞系表现出显著的抗肿瘤活性。
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