Kabalin J N, Gill H S
Urology Laboratories, Palo Alto Veterans Affairs Medical Center, California 94304.
Lasers Surg Med. 1994;14(2):145-54. doi: 10.1002/1096-9101(1994)14:2<145::aid-lsm1900140207>3.0.co;2-r.
Neodymium:YAG laser application was performed with the Urolase right angle laser fiber in a potato model and then in vivo in 29 canine prostates in an attempt to define dosimetry and optimal treatment parameters required to maximize tissue ablation and treatment efficacy. Depth and volume of prostatic tissue ablation for single, continuous laser applications with the Urolase fiber were measured at variable power settings from 20 to 60 watts, while holding total energy delivery constant. Peak tissue ablation was observed at 40 watts--up to a maximum of 21 mm tissue penetration in the canine model with a mode of 15 mm. The mean depth of tissue destruction at 40 watts power setting was 15.7 mm, with a mean volume of tissue ablation of 5.5 cc. The mean depth of tissue penetration at 40 watts was more than 30% greater than that observed at 60 watts, and the mean volume of tissue ablation was more than 60% greater than that observed at 60 watts. Holding the power setting constant at 40 watts, the extent of tissue ablation was measured for variable treatment times from 60 to 120 seconds. As treatment time was increased from 60 to 90 seconds, tissue ablation increased significantly. However, beyond 90 seconds of continuous laser application at 40 watts, a plateau in tissue effects was observed, with no real increase in tissue ablation between 90 and 120 seconds. Interruption or discontinuous laser application produced tissue effects which were significantly less than those observed for a single continuous 90 second laser treatment.
使用Urolase直角激光光纤在土豆模型中，然后在29只犬的前列腺体内进行钕钇铝石榴石激光应用，试图确定剂量学以及使组织消融和治疗效果最大化所需的最佳治疗参数。在20至60瓦的可变功率设置下，在保持总能量传递恒定的同时，测量了使用Urolase光纤进行单次连续激光应用时前列腺组织消融的深度和体积。在40瓦时观察到峰值组织消融——在犬模型中最大组织穿透深度达21毫米，模式为15毫米。在40瓦功率设置下，组织破坏的平均深度为15.7毫米，组织消融的平均体积为5.5立方厘米。40瓦时的平均组织穿透深度比60瓦时观察到的深度大30%以上，组织消融的平均体积比60瓦时观察到的大60%以上。将功率设置恒定在40瓦，测量了60至120秒可变治疗时间下的组织消融程度。随着治疗时间从60秒增加到90秒，组织消融显著增加。然而，在40瓦连续激光应用超过90秒后，观察到组织效应出现平稳期，在90至120秒之间组织消融没有实际增加。中断或不连续激光应用产生的组织效应明显小于单次连续90秒激光治疗所观察到的效应。
