发育中的视交叉的胚胎神经元表达L1和CD44，这两种细胞表面分子对视网膜轴突生长具有相反的作用。
Embryonic neurons of the developing optic chiasm express L1 and CD44, cell surface molecules with opposing effects on retinal axon growth.
作者信息
Sretavan D W, Feng L, Puré E, Reichardt L F
机构信息
Department of Physiology, University of California San Francisco.
出版信息
Neuron. 1994 May;12(5):957-75. doi: 10.1016/0896-6273(94)90307-7.
Abstract
The first retinal ganglion cell axons arriving at the embryonic mouse ventral diencephalon encounter an inverted V-shaped neuronal array defining the midline and posterior boundaries of the future optic chiasm. These neurons express L1, an immunoglobulin superfamily molecule known to promote retinal axon outgrowth, and CD44, a cell surface molecule that we find inhibits embryonic retinal axon growth in vitro. Incoming retinal axons do not penetrate this L1/CD44 neuron array, but turn to establish the characteristic X-shaped optic chiasm along the anterior border of this array. These results suggest that L1/CD44 neurons may serve as an anatomical template for retinal axon pathways at the embryonic mouse ventral diencephalon.
摘要
第一批抵达胚胎期小鼠腹侧间脑的视网膜神经节细胞轴突，会遇到一个倒V形的神经元阵列，该阵列界定了未来视交叉的中线和后边界。这些神经元表达L1，一种已知可促进视网膜轴突生长的免疫球蛋白超家族分子，以及CD44，一种我们发现在体外会抑制胚胎视网膜轴突生长的细胞表面分子。传入的视网膜轴突不会穿透这个L1/CD44神经元阵列，而是转向沿着该阵列的前缘形成特征性的X形视交叉。这些结果表明，L1/CD44神经元可能作为胚胎期小鼠腹侧间脑视网膜轴突通路的解剖学模板。
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