Sretavan D W, Puré E, Siegel M W, Reichardt L F
Department of Ophthalmology, University of California, San Francisco 94143, USA.
Science. 1995 Jul 7;269(5220):98-101. doi: 10.1126/science.7541558.
Mouse retinal ganglion cell axons growing from the eye encounter embryonic neurons at the future site of the optic chiasm. After in vivo ablation of these chiasm neurons with a monoclonal antibody and complement, retinal axons did not cross the midline and stalled at approximately the entry site into the chiasm region. Thus, in the mouse, the presence of early-generated neurons that reside at the site of the future chiasm is required for formation of the optic chiasm by retinal ganglion cell axons.
从眼睛生长出来的小鼠视网膜神经节细胞轴突，在视交叉的未来位置会遇到胚胎神经元。在用单克隆抗体和补体对这些视交叉神经元进行体内消融后，视网膜轴突没有穿过中线，而是在大约进入视交叉区域的入口处停滞。因此，在小鼠中，视网膜神经节细胞轴突形成视交叉需要早期生成的神经元存在于未来视交叉的位置。
