Ching N, Lumeng J, Pon E, Ching C Y
Department of Surgery, John A. Burns School of Medicine, University of Hawaii-Manoa.
Hawaii Med J. 1994 Feb;53(2):44-5, 49.
The hepatitis B antigen/antibody levels and natural killer cell activity status of chronic hepatitis B patients identified by the Hawaii State Department of Health were evaluated to select chronically infected hepatitis B patients for interferon therapy and to determine possible immunodeficiencies. The presence of hepatitis Be antigen denotes active replication of the virus. Ninety-five patients were studied: 17/95 (18%) had chronic active hepatitis B, 71/95 (75%) were hepatitis B carriers and 7/95 (7%) had seroconverted. NK activity to the erythroleukemia K562 cell and virus-infected HSV-1 cell of the chronic active and carrier population (P < .05) were lower than that of the control population and those who had spontaneously seroconverted. Of this population 18% were identified with active viral infection and would be candidates for interferon therapy.
对夏威夷州卫生部认定的慢性乙型肝炎患者的乙肝抗原/抗体水平及自然杀伤细胞活性状态进行评估，以选择适合接受干扰素治疗的慢性乙肝感染患者，并确定可能存在的免疫缺陷。乙肝e抗原的存在表明病毒正在活跃复制。对95名患者进行了研究：17/95（18%）患有慢性活动性乙型肝炎，71/95（75%）为乙肝携带者，7/95（7%）已发生血清学转换。慢性活动性患者和携带者群体对红白血病K562细胞及病毒感染的单纯疱疹病毒-1细胞的自然杀伤细胞活性（P <.05）低于对照组人群以及自发发生血清学转换的人群。该群体中有18%被认定为存在活跃的病毒感染，可能适合接受干扰素治疗。
