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Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor.实体瘤中血管通透性的增强由一氧化氮介导，且可被新型一氧化氮清除剂和一氧化氮合酶抑制剂所抑制。
Jpn J Cancer Res. 1994 Apr;85(4):331-4. doi: 10.1111/j.1349-7006.1994.tb02362.x.
2
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3
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本文引用的文献

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SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy.丝裂霉素与聚合物偶联大分子药物：癌症化疗中的优势
Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):169-85. doi: 10.1016/s0169-409x(00)00134-4.
2
Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction.咪唑啉氧基氮氧化物通过自由基反应对内皮衍生舒张因子/.NO的拮抗作用。
Biochemistry. 1993 Jan 26;32(3):827-32. doi: 10.1021/bi00054a013.
3
Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity.咪唑啉氧基氮氧化物通过其直接清除一氧化氮的活性对内毒素休克的治疗作用。
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A new approach to cancer chemotherapy: selective enhancement of tumor blood flow with angiotensin II.
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Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.肿瘤细胞分泌一种血管通透性因子，可促进腹水的积聚。
Science. 1983 Feb 25;219(4587):983-5. doi: 10.1126/science.6823562.
6
Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image.使用油性造影剂进行肿瘤的选择性药物靶向：增强治疗效果和X射线成像。
Cancer Res. 1984 May;44(5):2115-21.
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Increase in tumor vascular area due to increased blood flow by angiotensin II in rats.
J Natl Cancer Inst. 1985 Feb;74(2):453-9.
8
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.一氧化氮的释放构成了内皮源性舒张因子的生物活性。
Nature. 1987;327(6122):524-6. doi: 10.1038/327524a0.
9
Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothelial cells.从培养的内皮细胞释放的一氧化氮和内皮舒张因子的定量及动力学特性
Biochem Biophys Res Commun. 1988 Jul 15;154(1):236-44. doi: 10.1016/0006-291x(88)90675-4.
10
Increased vascular permeability in organs mediated by the systemic administration of lymphokine-activated killer cells and recombinant interleukin-2 in mice.小鼠体内通过全身注射淋巴因子激活的杀伤细胞和重组白细胞介素-2介导的器官血管通透性增加。
J Natl Cancer Inst. 1988 Apr 6;80(3):177-88. doi: 10.1093/jnci/80.3.177.

实体瘤中血管通透性的增强由一氧化氮介导，且可被新型一氧化氮清除剂和一氧化氮合酶抑制剂所抑制。

Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor.

作者信息

Maeda H, Noguchi Y, Sato K, Akaike T

机构信息

Department of Microbiology, Kumamoto University School of Medicine.

出版信息

Jpn J Cancer Res. 1994 Apr;85(4):331-4. doi: 10.1111/j.1349-7006.1994.tb02362.x.

DOI:10.1111/j.1349-7006.1994.tb02362.x
PMID:7515384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5919468/
Abstract

A newly discovered nitric oxide radical scavenger, an imidazolineoxyl N-oxide derivative, was used to investigate the role of nitric oxide radical (.NO) in the vascular permeability enhancement of solid tumor. Sarcoma-180 solid tumor in ddY mice was used for this experiment. Electron spin resonance spectroscopy was used to quantitate the reacted and unreacted scavenger. The results showed that extensive extravasation, assessed by intravenous injection of Evans blue, could be greatly suppressed by both .NO scavenger administered orally and .NO synthase inhibitor administrated intraperitoneally. This indicates that .NO is responsible for the vascular permeability in solid tumors.

摘要

一种新发现的一氧化氮自由基清除剂，即一种咪唑啉氧基N - 氧化物衍生物，被用于研究一氧化氮自由基（·NO）在实体瘤血管通透性增强中的作用。本实验采用ddY小鼠的肉瘤-180实体瘤。利用电子自旋共振光谱法定量已反应和未反应的清除剂。结果表明，通过静脉注射伊文思蓝评估的广泛血管外渗，可被口服的·NO清除剂和腹腔注射的·NO合酶抑制剂显著抑制。这表明·NO是实体瘤血管通透性的原因。