Lundmark J, Wålinder J, Alling C, Manniche P M, Dalgaard L
Department of Psychiatry, University Hospital, Linköping, Sweden.
Eur Neuropsychopharmacol. 1994 Mar;4(1):1-6. doi: 10.1016/0924-977x(94)90308-5.
This paper describes the effect of the selective serotonin reuptake inhibiting drug (SSRI), paroxetine, on cerebrospinal fluid concentrations of neurotransmitter metabolites in depressed patients. 5-Hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) were measured at baseline and after 3 weeks of treatment with 30 mg paroxetine daily. In line with similar studies on other SSRIs, influence on both the serotonin and noradrenaline metabolite was found. The mechanism behind the action of paroxetine on both 5-HIAA and MHPG is assumed to be an expression of the linkage between the serotonergic and noradrenergic systems in the brain. A frequently reported correlation between 5-HIAA and HVA was also found. The analysis of paroxetine in CSF proves the transportation of the drug into the central nervous system.
本文描述了选择性5-羟色胺再摄取抑制剂（SSRI）帕罗西汀对抑郁症患者脑脊液中神经递质代谢物浓度的影响。在基线水平以及每日服用30毫克帕罗西汀治疗3周后，分别测定了5-羟吲哚乙酸（5-HIAA）、3-甲氧基-4-羟基苯乙二醇（MHPG）和高香草酸（HVA）的含量。与其他SSRI的类似研究一致，发现其对5-羟色胺和去甲肾上腺素代谢物均有影响。帕罗西汀对5-HIAA和MHPG的作用机制被认为是大脑中5-羟色胺能系统与去甲肾上腺素能系统之间联系的一种表现。还发现了5-HIAA与HVA之间经常报道的相关性。脑脊液中帕罗西汀的分析证明了该药物可转运至中枢神经系统。
