van Leeuwen M A, van der Heijde D M, van Rijswijk M H, Houtman P M, van Riel P L, van de Putte L B, Limburg P C
Department of Rheumatology, University Hospital Groningen, The Netherlands.
J Rheumatol. 1994 Mar;21(3):425-9.
To investigate the relationship between different outcome and process measures in early rheumatoid arthritis (RA).
A 3-year prospective study of 149 patients with early RA (symptoms < 1 year at entry). Results of serial measurements of process variables were transformed into time integrated values for comparison with the outcome measures.
A highly significant correlation was found between the acute phase response, swollen joints, and radiological progression whereas none of these measures correlated with joint tenderness. Physical disability as estimated by the Health Assessment Questionnaire (HAQ) however, appeared to be determined by joint tenderness rather than by joint swelling.
In early RA, joint swelling and acute phase reactants appear to be the most appropriate process variables for the prediction of radiological outcome, whereas joint tenderness is a strong determinant of physical disability (HAQ).
探讨早期类风湿关节炎（RA）中不同结局指标与过程指标之间的关系。
对149例早期RA患者（入组时症状出现<1年）进行为期3年的前瞻性研究。将过程变量的系列测量结果转换为时间积分值，以便与结局指标进行比较。
发现急性期反应、关节肿胀与放射学进展之间存在高度显著的相关性，而这些指标均与关节压痛无关。然而，健康评估问卷（HAQ）评估的身体残疾似乎由关节压痛而非关节肿胀决定。
在早期RA中，关节肿胀和急性期反应物似乎是预测放射学结局最恰当的过程变量，而关节压痛是身体残疾（HAQ）的一个重要决定因素。
