Walton L J, Thornhill M H, Farthing P M
Department of Oral Pathology, London Hospital Medical College, England.
J Oral Pathol Med. 1994 Jul;23(6):262-8. doi: 10.1111/j.1600-0714.1994.tb00056.x.
Expression of intercellular adhesion molecule-1 (ICAM-1, CD54) and vascular cell adhesion molecule-1 (VCAM-1, CD106) was examined in oral lichen planus (OLP) and normal oral mucosa (NOM). Immunoperoxidase staining showed ICAM-1 expression by vascular endothelium in all biopsies of OLP and NOM whereas endothelial VCAM-1 staining was found in 2/7 NOM and 8/9 OLP. In the lamina propria of NOM occasional cells were ICAM-1 or VCAM-1 positive, and virtually no staining of intraepithelial dendritic cells was seen for either marker. Intraepithelial dendritic cells stained for ICAM-1 in 7/9 and VCAM-1 in 4/9 OLP biopsies. Double immunofluorescence showed dual labelling of Langerhans cells (LC) with CD1a and VCAM-1 in a further 5/12 cases of OLP, but there was no such staining in four NOM. This is the first report of LC staining with VCAM-1. Induction of ICAM-1 and VCAM-1 on LC and macrophages in OLP suggests these cells are activated and may contribute to the pathogenesis of OLP by presenting antigen to infiltrating lymphocytes.
研究了口腔扁平苔藓（OLP）和正常口腔黏膜（NOM）中细胞间黏附分子-1（ICAM-1，CD54）和血管细胞黏附分子-1（VCAM-1，CD106）的表达。免疫过氧化物酶染色显示，在OLP和NOM的所有活检组织中，血管内皮均表达ICAM-1，而在2/7的NOM和8/9的OLP中发现内皮VCAM-1染色。在NOM的固有层中，偶尔有细胞ICAM-1或VCAM-1呈阳性，两种标志物在上皮内树突状细胞中几乎均未见染色。在7/9的OLP活检组织中，上皮内树突状细胞ICAM-1染色阳性，4/9的OLP活检组织中上皮内树突状细胞VCAM-1染色阳性。双重免疫荧光显示，在另外5/12的OLP病例中，朗格汉斯细胞（LC）同时被CD1a和VCAM-1双重标记，但在4例NOM中未出现这种染色。这是关于LC被VCAM-1染色的首次报道。OLP中LC和巨噬细胞上ICAM-1和VCAM-1的诱导表明这些细胞被激活，可能通过将抗原呈递给浸润淋巴细胞而促进OLP的发病机制。
