在原发性和继发性II型混合性冷球蛋白血症患者的上清液和冷沉淀中，丙型肝炎病毒RNA的高流行率。

High prevalence of hepatitis C virus RNA in the supernatant and the cryoprecipitate of patients with essential and secondary type II mixed cryoglobulinemia.

作者信息

Bichard P, Ounanian A, Girard M, Baccard C, Rolachon A, Renversez J C, Cordonnier D, Seigneurin J M, Debru J L, Zarski J P

机构信息

Clinique d'Hépatogastroentérologie, Centre Hospitalier Régional et Universitaire de Grenoble, France.

出版信息

J Hepatol. 1994 Jul;21(1):58-63. doi: 10.1016/s0168-8278(94)80137-1.

DOI:10.1016/s0168-8278(94)80137-1

PMID:7525697

Abstract

Detection of hepatitis C virus RNA by polymerase chain reaction was performed in 26 patients with type II mixed cryoglobulinemia, and compared with anti-HCV antibody detection. The patients were divided into two groups according to etiology: 15 had essential type II mixed cryoglobulinemia and 11 had secondary type II mixed cryoglobulinemia. In the essential type II mixed cryoglobulinemia group, the prevalence of hepatitis C virus RNA detected by polymerase chain reaction was 60% in the supernatant and 93% in the cryoprecipitate. In the secondary type II mixed cryoglobulinemia group the prevalence of hepatitis C virus RNA was 45% in the supernatant and 55% in the cryoprecipitate. The differences between the two groups were not statistically significant. In both patient groups, detection of hepatitis C virus RNA in the cryoprecipitate was the most sensitive test for hepatitis C virus infection. These results suggest that hepatitis C virus might be involved in the origin of mixed cryoglobulinemia.

摘要

采用聚合酶链反应对26例II型混合性冷球蛋白血症患者进行丙型肝炎病毒RNA检测，并与抗-HCV抗体检测结果进行比较。根据病因将患者分为两组：15例为原发性II型混合性冷球蛋白血症，11例为继发性II型混合性冷球蛋白血症。在原发性II型混合性冷球蛋白血症组中，聚合酶链反应检测到的丙型肝炎病毒RNA在上清液中的患病率为60%，在冷沉淀物中的患病率为93%。在继发性II型混合性冷球蛋白血症组中，丙型肝炎病毒RNA在上清液中的患病率为45%，在冷沉淀物中的患病率为55%。两组之间的差异无统计学意义。在两个患者组中，冷沉淀物中丙型肝炎病毒RNA的检测是丙型肝炎病毒感染最敏感的检测方法。这些结果表明丙型肝炎病毒可能与混合性冷球蛋白血症的发病有关。