Redrup A C, Pearce F L
Department of Chemistry, University College London, UK.
Agents Actions. 1994 Jun;41 Spec No:C47-8. doi: 10.1007/BF02007761.
The effects of furosemide and bumetanide on immunologically stimulated rat peritoneal and human lung mast cells were compared. Furosemide and bumetanide had different modulatory actions on the rat peritoneal mast cell. Furosemide inhibited anti-IgE-induced histamine release. Preincubation of the cells with the drug, prior to anti-IgE stimulation, significantly reduced furosemide's inhibitory effect. In contrast, bumetanide potentiated anti-IgE-induced histamine secretion from the rat peritoneal mast cell. Both diuretics were modest inhibitors of anti-IgE-mediated histamine release from human lung mast cells. For furosemide, inhibition decreased with preincubation, while preincubation increased bumetanide's inhibitory action.
比较了呋塞米和布美他尼对免疫刺激的大鼠腹膜肥大细胞和人肺肥大细胞的作用。呋塞米和布美他尼对大鼠腹膜肥大细胞具有不同的调节作用。呋塞米抑制抗IgE诱导的组胺释放。在抗IgE刺激之前用该药物对细胞进行预孵育，可显著降低呋塞米的抑制作用。相反，布美他尼增强了抗IgE诱导的大鼠腹膜肥大细胞组胺分泌。两种利尿剂都是抗IgE介导的人肺肥大细胞组胺释放的适度抑制剂。对于呋塞米，预孵育后抑制作用减弱，而预孵育则增强了布美他尼的抑制作用。
