Russo D C, Williams D J, Grab D J
L. F. Kimball Research Institute, New York Blood Center, NY 10021.
Parasitol Res. 1994;80(6):487-92. doi: 10.1007/BF00932695.
Live antibody-coated Trypanosoma brucei parasites remove variable surface glycoprotein (VSG)-antibody complexes from their surface upon warming to 37 degrees C and evade antibody-activated complement lysis by both protein synthesis-dependent and protein synthesis-independent mechanisms. The protein synthesis-dependent process follows antibody-mediated trypanosome agglutination, whereas the protein synthesis-independent mechanism can occur in the absence of trypanosome agglutination. The latter process leads to a more rapid elimination of complement-fixing VSG-antibody complexes.
活的、被抗体包被的布氏锥虫寄生虫在升温至37摄氏度时会从其表面去除可变表面糖蛋白（VSG）-抗体复合物，并通过蛋白质合成依赖性和蛋白质合成非依赖性机制逃避抗体激活的补体裂解。蛋白质合成依赖性过程发生在抗体介导的锥虫凝集之后，而蛋白质合成非依赖性机制可在没有锥虫凝集的情况下发生。后一过程导致补体固定的VSG-抗体复合物更快地被清除。
