Ducos J, Bianchi-Mondain A M, Francois M, Boisset M, Vendrell J P, Barin F, Serre A, Larrey D
Institut National de la Santé et de la Recherche Médicale (INSERM) U249, Centre Hospitalier Universitaire Lapeyronie, Montpellier, France.
J Clin Microbiol. 1994 Oct;32(10):2613-5. doi: 10.1128/jcm.32.10.2613-2615.1994.
Hepatitis C virus-specific in vitro antibody production (HCV IVAP) by peripheral blood lymphocytes in 53 HCV antibody-positive patients was investigated in comparison with alanine aminotransferase (ALT) levels and HCV RNA in serum samples. All 29 HCV IVAP-positive patients were HCV RNA positive; 26 had elevated ALT levels. Among the 24 HCV IVAP-negative patients, 16 were HCV RNA negative, with 12 presenting normal ALT values. These data indicate that HCV IVAP results are highly correlated (P < 0.001) with HCV RNA results and ALT levels. Our study indicates that HCV IVAP can be used as a novel assay in the diagnosis and pathogenesis exploration of HCV infection.
对53例丙型肝炎病毒抗体阳性患者外周血淋巴细胞产生丙型肝炎病毒特异性体外抗体（HCV IVAP）的情况进行了研究，并与血清样本中的丙氨酸转氨酶（ALT）水平和HCV RNA进行了比较。29例HCV IVAP阳性患者均为HCV RNA阳性；26例ALT水平升高。在24例HCV IVAP阴性患者中，16例HCV RNA阴性，12例ALT值正常。这些数据表明，HCV IVAP结果与HCV RNA结果和ALT水平高度相关（P < 0.001）。我们的研究表明，HCV IVAP可作为丙型肝炎病毒感染诊断和发病机制探索的一种新检测方法。
