新生儿及婴儿大脑发育过程中的代谢改变：磁共振波谱质子成像评估
Metabolic alterations in the neonate and infant brain during development: evaluation with proton MR spectroscopy.
作者信息
Kimura H, Fujii Y, Itoh S, Matsuda T, Iwasaki T, Maeda M, Konishi Y, Ishii Y
机构信息
Department of Radiology, Fukui Medical School, Japan.
出版信息
Radiology. 1995 Feb;194(2):483-9. doi: 10.1148/radiology.194.2.7529934.
PURPOSE
To evaluate the usefulness of hydrogen-1 magnetic resonance (MR) spectroscopy in the evaluation of the developing brain.
MATERIALS AND METHODS
Localized MR spectra were obtained with an echo time of 272 msec from the brain of 78 neonates and infants aged 1 week to 100 months. All patients were retrospectively classified into three groups on the basis of neurologic development: abnormal (group 2, n = 21), normal despite minor neurologic signs (group 1, n = 23), and normal (group 0, n = 34).
RESULTS
Seventeen patients in group 2 and eight patients in group 1 revealed abnormally low N-acetylaspartate (NAA)/choline or NAA/creatine ratios compared with those obtained in group 0. MR spectroscopy was slightly more useful in the differentiation of patients in groups 2 and 1 (chi 2 test, P < .005) than MR imaging (P < .01).
CONCLUSION
H-1 MR spectroscopy provides prognostic information about the brain in healthy and neurologically damaged infants and augments the value of MR imaging.
目的
评估氢-1磁共振波谱（MR波谱）在发育中脑评估中的作用。
材料与方法
对78例年龄在1周龄至100个月的新生儿和婴儿的脑进行局部MR波谱检查，回波时间为272毫秒。所有患者根据神经发育情况进行回顾性分组：异常组（第2组，n = 21）、有轻微神经体征但正常组（第1组，n = 23）和正常组（第0组，n = 34）。
结果
与第0组相比，第2组中的17例患者和第1组中的8例患者显示N-乙酰天门冬氨酸（NAA）/胆碱或NAA/肌酸比值异常降低。MR波谱在区分第2组和第1组患者方面（卡方检验，P <.005）比MR成像（P <.01）略有用。
结论
氢-1 MR波谱可为健康及神经受损婴儿的脑提供预后信息，并增加MR成像的价值。
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