Schedlowski M, Flüge T, Richter S, Tewes U, Schmidt R E, Wagner T O
Division of Medical Psychology, Hannover Medical School, Germany.
Psychoneuroendocrinology. 1995;20(1):103-10. doi: 10.1016/0306-4530(94)00048-4.
The role of neuropeptides in the psychoneuroendocrinological stress response is largely unknown. In this study the effect of acute psychological stress on beta-endorphin and substance-P plasma concentrations was investigated and further the effect of different anxiety levels or control attributions on beta-endorphin or substance-P levels were determined. Blood samples were obtained from 47 inexperienced tandem-parachutists 2 h before, immediately after, and 1 h after a parachute jump and plasma concentrations of beta-endorphin and substance-P were analysed. Anxiety levels and control attributions were assessed by psychometric scales. Whereas substance-P concentrations seemed to be unaffected by the jump stress, there was a transient but significant increase in beta-endorphin levels immediately after jumping. However, subjects higher in state-anxiety at the point of jumping (exit) displayed higher substance-P values at all three time points compared to the "low-anxiety" jumpers. In addition, stress-induced beta-endorphin secretion was dependent on subjective control attributions.
神经肽在心理神经内分泌应激反应中的作用在很大程度上尚不清楚。在本研究中，我们调查了急性心理应激对β-内啡肽和P物质血浆浓度的影响，并进一步确定了不同焦虑水平或控制归因对β-内啡肽或P物质水平的影响。在47名没有经验的双人跳伞者进行跳伞前2小时、跳伞后立即以及跳伞后1小时采集血样，并分析β-内啡肽和P物质的血浆浓度。通过心理量表评估焦虑水平和控制归因。尽管P物质浓度似乎不受跳伞应激的影响，但跳伞后β-内啡肽水平立即出现短暂但显著的升高。然而，与“低焦虑”跳伞者相比，在跳伞（离开）时状态焦虑较高的受试者在所有三个时间点的P物质值都更高。此外，应激诱导的β-内啡肽分泌依赖于主观控制归因。
