Takada M, Yamamoto M, Saitoh Y
First Department of Surgery, Kobe University School of Medicine, Japan.
Pancreas. 1994 Nov;9(6):748-52. doi: 10.1097/00006676-199411000-00013.
The CD44 cell surface glycoprotein, which is the adhesion molecule of lymphocytes, has been suggested to be an important factor for the metastatic potential and invasive ability of cancer. We demonstrated the expression of CD44 in human pancreatic adenocarcinoma cells and normal cells by using flow cytometry (FACS-can) and immunohistological staining. CD44 was highly expressed in human pancreatic adenocarcinoma cells, while it was little expressed in normal human pancreas cells. These results indicate that the quantitative analysis of CD44 expression may be a useful diagnostic tool for pancreatic cancer.
CD44细胞表面糖蛋白是淋巴细胞的黏附分子，已被认为是影响癌症转移潜能和侵袭能力的一个重要因素。我们通过流式细胞术（FACS-can）和免疫组织化学染色，证实了CD44在人胰腺腺癌细胞和正常细胞中的表达情况。CD44在人胰腺腺癌细胞中高表达，而在正常胰腺细胞中低表达。这些结果表明，对CD44表达进行定量分析可能是一种有用的胰腺癌诊断工具。
