Takada M, Yamamoto M, Saitoh Y
First Department of Surgery, Kobe University School of Medicine, Japan.
Pancreas. 1994 Nov;9(6):753-7. doi: 10.1097/00006676-199411000-00014.
In our previous report (1), we showed the high expression of CD44 in human pancreatic adenocarcinomas cells. Pancreatic cancer aggressively invades surrounding tissues by penetrating basement membrane barriers. To examine the relation between the biological characteristics of human pancreatic adenocarcinoma cells and CD44 expression, we studied the function of CD44 in cell proliferation and cell invasion using a Matrigel basement membrane. The proliferation of human pancreatic adenocarcinoma cells was not affected by anti-CD44 antibody. On the contrary, invasion of the cells was suppressed by anti-CD44 antibody. This result suggests that the CD44 molecule plays an important role in pancreatic cancer cell invasion of the basement membrane.
在我们之前的报告（1）中，我们展示了CD44在人胰腺腺癌细胞中的高表达。胰腺癌通过穿透基底膜屏障积极侵袭周围组织。为了研究人胰腺腺癌细胞的生物学特性与CD44表达之间的关系，我们使用基质胶基底膜研究了CD44在细胞增殖和细胞侵袭中的功能。抗CD44抗体不影响人胰腺腺癌细胞的增殖。相反，抗CD44抗体抑制了细胞的侵袭。这一结果表明，CD44分子在胰腺癌细胞侵袭基底膜中起重要作用。
