Nkengasong J N, De Beenhouwer H, Claeys H, Nyambi P, Ayuk J, van der Groen G, Ndumbe P
Department of Infection and Immunity, Institute of Tropical Medicine, Antwerp, Belgium.
Am J Trop Med Hyg. 1995 Jan;52(1):98-100. doi: 10.4269/ajtmh.1995.52.98.
Information is lacking on the prevalence of hepatitis C virus (HCV) infection in most African countries. An algorithm based on a combination of enzyme immunoassays (EIAs) with different formats (a commercial test, an HCV antibody [Ab] III test, and an HCV core Ab EIA) was used to estimate the prevalence of HCV infection in different population groups from southern Cameroon. An overall high prevalence was observed, with a significant increasing trend for both sexes with respect to age. A high proportion (67.4%) of HCV-positive sera were viremic as demonstrated by the reverse transcription-polymerase chain reaction. We conclude that the prevalence of HCV is high in southern Cameroon and increases linearly with age.
大多数非洲国家缺乏丙型肝炎病毒（HCV）感染流行率的相关信息。基于不同形式的酶免疫测定（EIA）（一种商业检测、一种HCV抗体[Ab]III检测和一种HCV核心抗体EIA）组合的算法，用于估计喀麦隆南部不同人群中的HCV感染流行率。观察到总体流行率较高，且两性的流行率均随年龄呈显著上升趋势。通过逆转录聚合酶链反应证明，HCV阳性血清中有很大比例（67.4%）存在病毒血症。我们得出结论，喀麦隆南部HCV流行率较高，且随年龄呈线性增加。
