Tomaki M, Ichinose M, Miura M, Hirayama Y, Yamauchi H, Nakajima N, Shirato K
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):613-7. doi: 10.1164/ajrccm.151.3.7533601.
In experimental studies, tachykinins, especially substance P (SP), cause many of the pathophysiological features of neurogenic inflammation. It is unclear whether these peptides are involved in human airway inflammation in diseases such as asthma and chronic bronchitis. To elucidate the relation between neurogenic inflammation and airway inflammatory diseases, we examined the SP concentration in sputum after hypertonic saline inhalation challenge in patients with asthma, patients with chronic bronchitis, and normal volunteers. SP concentration was measured by radioimmunoassay. The sputum SP concentration was significantly higher in patients with asthma (mean +/- SEM, 17.7 +/- 2.4 fmol/ml; p < 0.01) and patients with chronic bronchitis (25.6 +/- 5.5 fmol/ml; p < 0.01) than in normal volunteers (1.1 +/- 0.4 fmol/ml). In patients with asthma, the SP concentration was significantly related to the eosinophil cell count in induced sputum. In all subjects, the SP concentration in induced sputum correlated with FEV1/FVC. These data suggest that neurogenic inflammation may be involved in the airway inflammatory process and subsequent airway narrowing not only in asthma but also in chronic bronchitis.
在实验研究中，速激肽，尤其是P物质（SP），会引发神经源性炎症的许多病理生理特征。目前尚不清楚这些肽是否参与哮喘和慢性支气管炎等疾病中的人类气道炎症。为了阐明神经源性炎症与气道炎性疾病之间的关系，我们检测了哮喘患者、慢性支气管炎患者和正常志愿者在高渗盐水吸入激发后痰液中的SP浓度。通过放射免疫测定法测量SP浓度。哮喘患者（平均值±标准误，17.7±2.4 fmol/ml；p<0.01）和慢性支气管炎患者（25.6±5.5 fmol/ml；p<0.01）痰液中的SP浓度显著高于正常志愿者（1.1±0.4 fmol/ml）。在哮喘患者中，SP浓度与诱导痰液中的嗜酸性粒细胞计数显著相关。在所有受试者中，诱导痰液中的SP浓度与FEV1/FVC相关。这些数据表明，神经源性炎症可能不仅参与哮喘，也参与慢性支气管炎的气道炎症过程及随后的气道狭窄。
