Nahaczewska W, Kudrewicz-Hubicka Z, Owczarek H, Kopeć Z
Katedry i Zakładu Analityki Medycznej Ak. Med. we Wrocławiu.
Wiad Lek. 1993 Dec;46(23-24):906-11.
An attempts was made at evaluation of the changes of acute phase proteins-seromucoid (BRS), alpha 1-acid glycoprotein (alpha 1-AGP), alpha 1-antitrypsin (alpha 1-AT), haptoglobin (Hp), C3 protein of complement system (C3), C1 esterase inhibitor (C1-INH), and transferrin (Tf) in the serum of children with rheumatoid arthritis. The patients were divided into clinical and age groups. The studies carried out have shown in ill children increase of BRS, alpha 1-AGP, alpha 1-AT, Hp, and C1-INH levels, During remission increased levels of alpha 1-AGP and Hp persisted. In the studied clinical groups a positive correlation was found between the intensity of changes of the studied indices and the degree of disease activity. In the age groups greater increase of the levels of the studied acute phase proteins was found in the group of preschool children and the group of puberty spurt. The obtained results suggest that the determination of acute phase proteins may be useful in laboratory investigation of children with rheumatoid arthritis.
对类风湿性关节炎患儿血清中的急性期蛋白——血清类粘蛋白（BRS）、α1-酸性糖蛋白（α1-AGP）、α1-抗胰蛋白酶（α1-AT）、触珠蛋白（Hp）、补体系统C3蛋白（C3）、C1酯酶抑制剂（C1-INH）和转铁蛋白（Tf）的变化进行了评估。将患者分为临床组和年龄组。所进行的研究表明，患病儿童的BRS、α1-AGP、α1-AT、Hp和C1-INH水平升高。在缓解期，α1-AGP和Hp水平持续升高。在所研究的临床组中，发现所研究指标的变化强度与疾病活动程度之间存在正相关。在年龄组中，学龄前儿童组和青春期发育突增组中所研究的急性期蛋白水平升高更为明显。所得结果表明，急性期蛋白的测定可能有助于类风湿性关节炎患儿的实验室检查。
