Zieleniewski W, Zieleniewski J
Department of Clinical Endocrinology, University School of Medicine, Lodz, Poland.
Peptides. 1995;16(1):175-6. doi: 10.1016/0196-9781(94)e0089-n.
The influence of neurotensin (NT) and substance P (SP) on the early stage of adrenal regeneration was investigated. Neurotensin (5 and 50 micrograms/kg) and SP (10 and 100 micrograms/kg) were given to rats subjected to adrenal enucleation combined with contralateral adrenalectomy. The mitotic index was employed to assess cell growth, and plasma corticosterone was determined by a radioimmunological assay. The animals were killed 4 and 8 days after operation. Neurotensin did not evoke any significant changes either in the proliferation ratio or corticosterone production of regenerating adrenal cortex. However, it was found that SP (100 micrograms/kg) stimulated both the proliferation and steroidogenesis on the eighth day after operation.
研究了神经降压素（NT）和P物质（SP）对肾上腺再生早期阶段的影响。将神经降压素（5和50微克/千克）和SP（10和100微克/千克）给予接受肾上腺去核联合对侧肾上腺切除术的大鼠。采用有丝分裂指数评估细胞生长，并通过放射免疫测定法测定血浆皮质酮。在术后4天和8天处死动物。神经降压素对再生肾上腺皮质的增殖率或皮质酮产生均未引起任何显著变化。然而，发现SP（100微克/千克）在术后第8天刺激了增殖和类固醇生成。
