Zieleniewski W
Institute of Endocrinology, Lodz, Poland.
Eur J Endocrinol. 1997 Jan;136(1):121-2. doi: 10.1530/eje.0.1360121.
Endothelin-1 (ET-1), a potent vasoconstrictor, was found to act in non-vascular tissues, for example it enhanced aldosterone output from adrenal zona glomerulosa. As the adrenal cortex is capable of regeneration after enucleation, it seemed of interest to study the effects of ET-1 on adrenocortical regeneration. The study was performed on adult rats subjected to left adrenal enucleation combined with contralateral adrenalectomy. Mitotic index was employed to assess the proliferation of regenerating adrenal cortex cells. Plasma corticosterone was measured by a standard RIA kit. ET-1 significantly raised the mitotic index of regenerating rat adrenal cortex by six days after surgery. On the other hand, nifedipine reduced the proliferation ratio and abolished the stimulatory influence of ET-1. Similarly, ET-1 enhanced corticosterone output from the regenerating adrenal cortex, and this could be prevented by the addition of nifedipine. This study has shown that ET-1 might act as a regulatory factor on the regenerating adrenal cortex via calcium channels.
内皮素-1（ET-1）是一种强效血管收缩剂，被发现可作用于非血管组织，例如它能增强肾上腺球状带的醛固酮分泌。由于肾上腺皮质在摘除术后能够再生，研究ET-1对肾上腺皮质再生的影响似乎很有意义。该研究在成年大鼠身上进行，这些大鼠接受了左肾上腺摘除并联合对侧肾上腺切除术。采用有丝分裂指数来评估再生肾上腺皮质细胞的增殖情况。血浆皮质酮通过标准放射免疫分析试剂盒进行测定。术后六天，ET-1显著提高了再生大鼠肾上腺皮质的有丝分裂指数。另一方面，硝苯地平降低了增殖率并消除了ET-1的刺激作用。同样，ET-1增强了再生肾上腺皮质的皮质酮分泌，而添加硝苯地平可以阻止这种情况。这项研究表明，ET-1可能通过钙通道对再生肾上腺皮质起调节因子的作用。
