Zieleniewski W
Department of Clinical Endocrinology, Institute of Endocrinology, Lodz, Poland.
Life Sci. 1990;46(25):1851-5. doi: 10.1016/0024-3205(90)90237-l.
The effect of verapamil, a calcium channel antagonist, on proliferation and steroidogenesis was investigated in regenerating rat adrenal cortex. Verapamil was given subcutaneously in two doses (1 and 5 mg/kg) to male Wistar rats subjected to adrenal enucleation combined with contralateral adrenalectomy. It was found that verapamil inhibited the mitotic activity of adrenocortical cells on the 4th and 8th day after surgery in a dose-dependent manner. However, no changes in corticosterone secretion were observed.
在再生大鼠肾上腺皮质中研究了钙通道拮抗剂维拉帕米对增殖和类固醇生成的影响。对接受肾上腺去核联合对侧肾上腺切除术的雄性Wistar大鼠皮下注射两种剂量（1和5mg/kg）的维拉帕米。结果发现，维拉帕米在术后第4天和第8天以剂量依赖的方式抑制肾上腺皮质细胞的有丝分裂活性。然而，未观察到皮质酮分泌的变化。
