Hauptmann G, Tongio M M, Klein J, Mayer S
Rev Fr Transfus Immunohematol. 1978 Dec;21(5):1053-9. doi: 10.1016/s0338-4535(78)80002-6.
Since the discovery of the linkage between HLA and Bf by Allen in 1974 several reports have shown a very close linkage between Bf and HLA-B. We have studied 19 families with 81 offsprings for the linkage between HLA (A,B) and Bf. The total "lod scores" in our material for the linkage between HLA-B and Bf is 17,167 at theta = 0.00. No recombination was observed between HLA-B and Bf. One recombination out of 79 informative meiotic divisions was observed between HLA-A and Bf. This result would mean that the Bf locus is about 1.3% recombination fraction far from the HLA-A locus. Our estimation is in good agreement with the results of other authors. However the estimation of recombination fractions is only an arbitrary mean to map genetic loci on chromosomal regions and family studies of cases with intra-HLA cross-overs are of more interest. All available data from the litterature are in favour to a very close linkage between Bf and HLA-B and to a situation of the Bf locus between HLA-B and HLA-D. However some conflicting data on Bf gene mapping have been published. More precise informations may be obtained as soon as a more exact structure of the HLA region, in particular of the HLA-D region, will be known.
自1974年艾伦发现HLA与Bf之间的连锁关系以来，已有多篇报道表明Bf与HLA - B之间存在非常紧密的连锁关系。我们研究了19个家庭，共有81名后代，以研究HLA（A、B）与Bf之间的连锁关系。在我们的研究材料中，HLA - B与Bf之间连锁的总“lod分数”在θ = 0.00时为17.167。未观察到HLA - B与Bf之间发生重组。在HLA - A与Bf之间，79次信息性减数分裂中观察到1次重组。这一结果意味着Bf基因座与HLA - A基因座的重组率约为1.3%。我们的估计与其他作者的结果高度一致。然而，重组率的估计只是在染色体区域定位基因座的一种任意方法，对HLA内部发生交叉的病例进行家系研究更有意义。文献中的所有现有数据都支持Bf与HLA - B之间存在非常紧密的连锁关系，以及Bf基因座位于HLA - B与HLA - D之间的情况。然而，关于Bf基因定位的一些相互矛盾的数据已经发表。一旦了解了HLA区域，特别是HLA - D区域的更精确结构，就可以获得更精确的信息。
