Chibazakura T, Kawamura F, Asai K, Takahashi H
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
J Bacteriol. 1995 Aug;177(15):4520-3. doi: 10.1128/jb.177.15.4520-4523.1995.
Transcriptional analyses of the Bacillus subtilis sporulation initiator gene spo0A revealed that promoter switching from the vegetative (Pv) to the sporulation-specific (Ps) promoter did not occur in the spo0A, spo0B, spo0E, spo0F, and spo0H mutants. The sof-1 mutation in spo0A restored the promoter switching in the spo0F mutant. These results strongly suggest that Spo0A plays a central role in the regulation of its own promoter switching.
枯草芽孢杆菌芽孢形成起始基因spo0A的转录分析表明,在spo0A、spo0B、spo0E、spo0F和spo0H突变体中,启动子未从营养型(Pv)切换为芽孢形成特异性(Ps)启动子。spo0A中的sof-1突变恢复了spo0F突变体中的启动子切换。这些结果有力地表明,Spo0A在其自身启动子切换的调控中起核心作用。