枯草芽孢杆菌孢子形成起始时spo0突变对spo0A启动子转换的影响。
Effects of spo0 mutations on spo0A promoter switching at the initiation of sporulation in Bacillus subtilis.
作者信息
Chibazakura T, Kawamura F, Asai K, Takahashi H
机构信息
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
出版信息
J Bacteriol. 1995 Aug;177(15):4520-3. doi: 10.1128/jb.177.15.4520-4523.1995.
Abstract
Transcriptional analyses of the Bacillus subtilis sporulation initiator gene spo0A revealed that promoter switching from the vegetative (Pv) to the sporulation-specific (Ps) promoter did not occur in the spo0A, spo0B, spo0E, spo0F, and spo0H mutants. The sof-1 mutation in spo0A restored the promoter switching in the spo0F mutant. These results strongly suggest that Spo0A plays a central role in the regulation of its own promoter switching.
摘要
枯草芽孢杆菌芽孢形成起始基因spo0A的转录分析表明，在spo0A、spo0B、spo0E、spo0F和spo0H突变体中，启动子未从营养型（Pv）切换为芽孢形成特异性（Ps）启动子。spo0A中的sof-1突变恢复了spo0F突变体中的启动子切换。这些结果有力地表明，Spo0A在其自身启动子切换的调控中起核心作用。
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