Abb J, Abb H, Deinhardt F
Blut. 1984 May;48(5):285-9. doi: 10.1007/BF00320399.
The influence of donor age on the production of interferon (IFN) alpha and IFN gamma by human peripheral blood mononuclear cells in vitro has been studied. The results demonstrate an age-related decline of the capacity to synthesize and secrete antiviral activity. Yields of virus-induced IFN alpha and lectin-induced IFN gamma were significantly decreased in mononuclear cell cultures from older subjects (greater than 50 years) when compared to those of younger subjects (less than 50 years). The observed deficiency of IFN production may be involved in the increased susceptibility of aged humans to viral infections and malignant diseases.
已研究供体年龄对人外周血单个核细胞体外产生α干扰素（IFN）和γ干扰素的影响。结果表明，合成和分泌抗病毒活性的能力随年龄下降。与年轻受试者（小于50岁）相比，老年受试者（大于50岁）的单核细胞培养物中病毒诱导的α干扰素和凝集素诱导的γ干扰素产量显著降低。观察到的干扰素产生不足可能与老年人对病毒感染和恶性疾病易感性增加有关。
