用于血管填充的羟乙基淀粉在隐球菌抗原乳胶凝集试验中的干扰作用。
Interference by hydroxyethyl starch used for vascular filling in latex agglutination test for cryptococcal antigen.
作者信息
Millon L, Barale T, Julliot M C, Martinez J, Mantion G
机构信息
Laboratoire de Parasitologie-Mycologie, Hopital Jean Minjoz, Besançon, France.
出版信息
J Clin Microbiol. 1995 Jul;33(7):1917-9. doi: 10.1128/jcm.33.7.1917-1919.1995.
Abstract
The glucuronoxylomannan component of the Cryptococcus neoformans capsular polysaccharide confers serotype specificity, and its detection in cerebrospinal fluid or serum by the latex agglutination test is used for diagnosis. Low-molecular-weight hydroxyethyl starches can be used as an alternative to albumin for vascular filling. This study reports the occurrence of a false-positive result with the Pastorex Cryptococcus test (Sanofi Diagnostics Pasteur, Marnes la Coquette, France) for a patient receiving hydroxyethyl starch characterized by a substitution ratio of 0.6 (Elohes, Biosedra, Sèvres, France).
摘要
新型隐球菌荚膜多糖的葡糖醛酸木甘露聚糖成分决定了血清型特异性，通过乳胶凝集试验在脑脊液或血清中检测该成分可用于诊断。低分子量羟乙基淀粉可作为白蛋白的替代品用于血管填充。本研究报告了一名接受取代率为0.6的羟乙基淀粉（法国塞夫尔市Biosedra公司的Elohes）治疗的患者，其使用法国马恩拉科盖特市赛诺菲巴斯德诊断公司的Pastorex新型隐球菌检测出现假阳性结果。
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