Oen A L, de Boer M F, Hop W C, Knegt P
Department of Otorhinolaryngology/Head and Neck Surgery, University Hospital Rotterdam, Dijkzigt/Dr. Daniel den Hoed, The Netherlands.
Eur Arch Otorhinolaryngol. 1995;252(4):222-8. doi: 10.1007/BF00179915.
A retrospective study was performed to examine the results of treatment for cervical lymph node metastases from an unknown primary between 1978 and 1988. We reviewed 66 patients treated with either surgery and/or radiotherapy (n = 41), radiation therapy and chemotherapy (n = 11), combined modality treatment with surgery (n = 8) or with management delayed to proven disease (n = 6). The male-to-female ratio was 5.6 to 1, and the median age was 64 years (range, 15-89 years). Intercurrent death-corrected 5-year survival was 50%. The most important prognostic factors were M category and involvement of supraclavicular nodes. Primary tumor was eventually discovered in 12 patients during follow-up, 6 of whom received treatment with curative intent. The most common site of primary tumor was found to be the lung (n = 5).
进行了一项回顾性研究，以检查1978年至1988年间不明原发灶的颈部淋巴结转移的治疗结果。我们回顾了66例接受手术和/或放疗（n = 41）、放疗和化疗（n = 11）、联合手术的综合治疗（n = 8）或延迟治疗至确诊疾病（n = 6）的患者。男女比例为5.6比1，中位年龄为64岁（范围15 - 89岁）。校正并发死亡后的5年生存率为50%。最重要的预后因素是M分类和锁骨上淋巴结受累情况。随访期间最终在12例患者中发现了原发肿瘤，其中6例接受了根治性治疗。发现原发肿瘤最常见的部位是肺（n = 5）。
