Rachmat L, Vreeburg G C, de Vries N, Hordijk G J, Lubsen H, Manni J J, Snow G B
Department of Otolaryngology/Head and Neck Surgery, Academic Hospital Nijmegen, The Netherlands.
Eur J Cancer. 1993;29A(8):1096-9. doi: 10.1016/s0959-8049(05)80295-3.
The aim of this retrospective study was to investigate the usefulness and feasibility of twice-yearly bronchoscopy and sputum cytology in patients with laryngeal cancer. In 170 selected patients, 500 (both initial and during follow-up) bronchoscopies were performed. There was a maximum follow-up of 34 months. 5 (2.8%) male patients developed lung cancer. In only 2 of them was the diagnosis based on bronchoscopy alone. After treatment with curative intent, both patients developed a recurrent lung carcinoma. According to most patients' experience, regular bronchoscopy is unpleasant. It is concluded that twice-yearly bronchoscopy and sputum cytology in patients with laryngeal cancer is not useful as a routine procedure. At present, chemoprevention of second primary tumours seems the most promising adjunctive treatment modality.
这项回顾性研究的目的是调查每年两次支气管镜检查和痰细胞学检查在喉癌患者中的实用性和可行性。在170例选定患者中，共进行了500次（包括初始检查和随访期间）支气管镜检查。最长随访时间为34个月。5例（2.8%）男性患者发生了肺癌。其中仅2例是单纯通过支气管镜检查确诊的。在进行根治性治疗后，这两名患者均出现了复发性肺癌。根据大多数患者的经验，定期支气管镜检查会带来不适。得出的结论是，每年两次对喉癌患者进行支气管镜检查和痰细胞学检查作为常规程序并无用处。目前，化学预防第二原发性肿瘤似乎是最有前景的辅助治疗方式。
