Stevens D L, Bryant A E, Hackett S P
Infectious Disease Section, Department of Veterans Affairs Medical Center, Boise, Idaho, USA.
Clin Infect Dis. 1995 Jun;20 Suppl 2:S154-7. doi: 10.1093/clinids/20.supplement_2.s154.
The efficacy of an antibiotic in human or experimental infection is presumed to be proportional to its in vitro antimicrobial activity, yet antibiotics having comparable in vitro activity may have markedly different efficacies in vivo. For example, we have reported that clindamycin is more efficacious than penicillin in experimental gas gangrene caused by Clostridium perfringens in animals. To explain these differences, we compared the dynamics of bacterial killing and suppression of toxin synthesis. In addition, we investigated the ability of clindamycin and penicillin to modulate lipopolysaccharide-induced cytokine production in human peripheral blood mononuclear cells. Our results suggest that clindamycin affects protein synthesis in both prokaryotic and eukaryotic cells. These data may, in part, explain why the efficacy of clindamycin is greater than that of penicillin and demonstrate that clindamycin may be important immune modulator.
抗生素在人类感染或实验性感染中的疗效被认为与其体外抗菌活性成正比，然而，具有相当体外活性的抗生素在体内的疗效可能有显著差异。例如，我们曾报道，在动物实验性产气荚膜梭菌引起的气性坏疽中，克林霉素比青霉素更有效。为了解释这些差异，我们比较了细菌杀灭动力学和毒素合成抑制情况。此外，我们研究了克林霉素和青霉素调节人外周血单核细胞中脂多糖诱导的细胞因子产生的能力。我们的结果表明，克林霉素影响原核细胞和真核细胞中的蛋白质合成。这些数据可能部分解释了为什么克林霉素的疗效大于青霉素，并表明克林霉素可能是一种重要的免疫调节剂。
