Yazawa S, Toshimori H, Nakatsuru K, Katakami H, Takemura J, Matsukura S
Third Department of Internal Medicine, Miyazaki Medical College.
Intern Med. 1995 Jun;34(6):584-8. doi: 10.2169/internalmedicine.34.584.
A 65-year-old woman noticed a rapidly enlarging neck mass with tenderness and complained of dyspnea. She was diagnosed as having anaplastic thyroid carcinoma. She died of respiratory failure 14 days after admission. Marked leukocytosis and hypercalcemia were observed in the clinical course. Both serum granulocyte-colony-stimulating factor and parathyroid hormone-related protein levels were elevated. The cancerous tissue was also immunohistochemically stained for both peptides. We conclude that the leukocytosis and hypercalcemia of this patient were induced by these two factors produced by the tumor.
一名65岁女性注意到颈部肿物迅速增大且有压痛，并伴有呼吸困难。她被诊断为间变性甲状腺癌。入院14天后死于呼吸衰竭。临床过程中观察到明显的白细胞增多和高钙血症。血清粒细胞集落刺激因子和甲状旁腺激素相关蛋白水平均升高。癌组织也对这两种肽进行了免疫组化染色。我们得出结论，该患者的白细胞增多和高钙血症是由肿瘤产生的这两种因素引起的。
