脂蛋白(a)与糖尿病患者的视网膜病变无关。
Lp(a) is not related to retinopathy in diabetic subjects.
作者信息
Haffner S M, Klein B E, Moss S E, Klein R
机构信息
Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio Department of Medicine, USA.
出版信息
Eur J Ophthalmol. 1995 Apr-Jun;5(2):119-23. doi: 10.1177/112067219500500209.
PURPOSE
To examine the association between Lp(a) concentrations and the severity of retinopathy in 22 younger-onset and 48 older-onset diabetic subjects from the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR), a population-based study of diabetic retinopathy.
METHODS
We used a subset of the WESDR population with standardized protocols and stereoscopic color fundus photography to determine the severity of diabetic retinopathy in relation to Lp(a) concentrations. Lp(a) concentrations were measured by a monoclonal anti-Lp(a) antibody.
RESULTS
Lp(a) levels were not significantly different between younger-onset or older-onset subjects with and without retinopathy.
CONCLUSION
Our results do not support a link between higher levels of Lp(a) and severe retinopathy in either younger-onset or older-onset diabetic subjects but this needs confirmation in larger prospective studies.
目的
在威斯康星糖尿病视网膜病变流行病学研究（WESDR，一项基于人群的糖尿病视网膜病变研究）中，研究22名早发型和48名晚发型糖尿病患者的脂蛋白(a)[Lp(a)]浓度与视网膜病变严重程度之间的关联。
方法
我们使用WESDR人群的一个子集，采用标准化方案和立体彩色眼底摄影来确定糖尿病视网膜病变的严重程度与Lp(a)浓度的关系。Lp(a)浓度通过单克隆抗Lp(a)抗体进行测量。
结果
有视网膜病变和无视网膜病变的早发型或晚发型受试者之间的Lp(a)水平无显著差异。
结论
我们的结果不支持较高水平的Lp(a)与早发型或晚发型糖尿病患者的严重视网膜病变之间存在关联，但这需要在更大规模的前瞻性研究中得到证实。
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