Fayers P
MRC Cancer Trials Office, Cambridge, UK.
Qual Life Res. 1995 Aug;4(4):343-52. doi: 10.1007/BF01593887.
The UK Medical Research Council (MRC) Daily Diary Card for quality of life (QOL) assessment was first designed over ten years ago, and since then has been in continuous use in cancer clinical trials organized by the MRC Cancer Trials Office. However, clinical trials using this technique have only reached maturity since 1989 and later. Thus it is timely to review the experiences gained by use of this method of assessing QOL. Results from a series of clinical trials confirm that the Daily Diary Card appears to be a valid, reliable and sensitive instrument which is able to detect the transient changes in health and QOL which occur on a day to day basis during therapy for cancer. However, in early studies we also encountered a number of problems which were addressed during later MRC trials; we believe that many of these are of general importance to any investigation of QOL in patients, many of the issues raised remain controversial, and the practical lessons learned from applying the Diary Card will be of relevance to those planning future studies of QOL assessment.
英国医学研究理事会（MRC）用于生活质量（QOL）评估的每日日记卡于十多年前首次设计，从那时起一直在MRC癌症试验办公室组织的癌症临床试验中持续使用。然而，使用这种技术的临床试验直到1989年及以后才成熟。因此，及时回顾使用这种评估生活质量方法所获得的经验是很有必要的。一系列临床试验的结果证实，每日日记卡似乎是一种有效、可靠且敏感的工具，能够检测出癌症治疗期间每天出现的健康和生活质量的短暂变化。然而，在早期研究中我们也遇到了一些问题，这些问题在后来的MRC试验中得到了解决；我们认为其中许多问题对于任何患者生活质量调查都具有普遍重要性，许多提出的问题仍然存在争议，并且从应用日记卡中学到的实际经验教训将与那些计划未来生活质量评估研究的人相关。
