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母源抗体对家畜口蹄疫主动免疫的干扰。

The interference by maternally-derived antibody with active immunization of farm animals against foot-and-mouth disease.

作者信息

Kitching R P, Salt J S

机构信息

Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, UK.

出版信息

Br Vet J. 1995 Jul-Aug;151(4):379-89. doi: 10.1016/s0007-1935(95)80127-8.

Abstract

Foot-and-mouth disease (FMD) is a highly contagious disease affecting ruminants and pigs. In countries in which control of FMD relies predominantly on vaccination, young stock ingest specific anti-FMD virus antibodies in the colostrum. This maternally-derived antibody (MDA) provides immediate protection against infection with FMD virus, but also interferes with the development of active immunity following vaccination. However, susceptibility to infection precedes the ability to respond to vaccination in the presence of MDA. Currently available vaccines cannot overcome this inhibitory effect of MDA, and protection of young stock can only be provided by their isolation from FMD virus.

摘要

口蹄疫(FMD)是一种影响反刍动物和猪的高度传染性疾病。在主要依靠疫苗接种来控制口蹄疫的国家,幼畜会在初乳中摄入特定的抗口蹄疫病毒抗体。这种母源抗体(MDA)可提供针对口蹄疫病毒感染的即时保护,但也会干扰接种疫苗后主动免疫的发展。然而,在存在MDA的情况下,感染易感性先于对疫苗接种作出反应的能力出现。目前可用的疫苗无法克服MDA的这种抑制作用,而保护幼畜只能通过将它们与口蹄疫病毒隔离来实现。

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