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骨髓瘤肿瘤与细胞毒性胸腺来源淋巴细胞的反应性周期性丧失。

Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes.

作者信息

Russell J H, Hale A H, Ginns L C, Eisen H N

出版信息

Proc Natl Acad Sci U S A. 1978 Jan;75(1):441-5. doi: 10.1073/pnas.75.1.441.

DOI:10.1073/pnas.75.1.441
PMID:75547
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC411265/
Abstract

During each transplantation passage of a line of mouse myeloma tumor MOPC-315 through syngeneic (BALB/c) hosts, the tumor cells lose reactivity with cytotoxic thymus-derived lymphocytes directed against products of the BALB/c major histocompatibility complex (H-2d) and regain reactivity on transfer to fresh hosts. In contrast to this cyclical change, the tumor cells remain uniformly reactive with anti-H-2d alloantisera throughout the transplantation cycle.

摘要

在小鼠骨髓瘤肿瘤细胞系MOPC - 315通过同基因（BALB/c）宿主进行的每次移植传代过程中，肿瘤细胞失去了与针对BALB/c主要组织相容性复合体（H - 2d）产物的细胞毒性胸腺来源淋巴细胞的反应性，并在转移至新宿主时恢复反应性。与这种周期性变化相反，肿瘤细胞在整个移植周期中对抗H - 2d同种抗血清保持一致的反应性。

相似文献

1
Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes.骨髓瘤肿瘤与细胞毒性胸腺来源淋巴细胞的反应性周期性丧失。
Proc Natl Acad Sci U S A. 1978 Jan;75(1):441-5. doi: 10.1073/pnas.75.1.441.
2
Loss of reactivity of a BALB/c myeoloma tumor with allogeneic and syngeneic cytotoxic T lymphocytes.BALB/c骨髓瘤肿瘤与同种异体和同基因细胞毒性T淋巴细胞反应性的丧失。
Eur J Immunol. 1978 Sep;8(9):640-5. doi: 10.1002/eji.1830080907.
3
Loss of reactivity of a myeloma tumor with H-2 compatible thymus-derived lymphocytes.骨髓瘤肿瘤与H-2相容的胸腺来源淋巴细胞反应性丧失。
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4
Periodic fluctuations in resistance of a myeloma tumor (MOPC-315-el) to cytotoxic T lymphocytes.骨髓瘤肿瘤（MOPC - 315 - el）对细胞毒性T淋巴细胞的抗性的周期性波动。
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6
Cyclical changes in susceptibility of a myeloma tumor (LPC-1) to immune destruction. I. Changes in reactivity with cytotoxic T lymphocytes and anti-H-2d sera.骨髓瘤肿瘤（LPC-1）对免疫破坏敏感性的周期性变化。I. 与细胞毒性T淋巴细胞和抗H-2d血清反应性的变化。
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Myeloma proteins as tumor-specific transplantation antigens.骨髓瘤蛋白作为肿瘤特异性移植抗原。
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9
Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.针对H-2复合体K和D位点产物的同种抗血清对三硝基苯基衍生化靶细胞的细胞介导细胞溶解作用的抑制。
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Hybrid cell lines secreting monoclonal antibody specific for major histocompatibility antigens of the mouse.分泌针对小鼠主要组织相容性抗原的单克隆抗体的杂交细胞系。
Nature. 1978 Jan 19;271(5642):249-51. doi: 10.1038/271249a0.

引用本文的文献

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Herman N. Eisen: Mentor to many.赫尔曼·N·艾森：众多人的导师。
Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1650-1. doi: 10.1073/pnas.1500050112. Epub 2015 Jan 23.
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Variation of expression of histocompatibility antigens on tumor cells: absence of H-2Kk-gene products from a gross-virus-induced leukemia in BALB.K.肿瘤细胞上组织相容性抗原表达的变化：BALB.K品系中一种粗病毒诱导的白血病缺乏H-2Kk基因产物
Immunogenetics. 1981;14(3-4):323-39. doi: 10.1007/BF00342201.
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Elicitation of anti-vesicular stomatitis virus cytotoxic T lymphocytes by using purified viral and cellular antigens incorporated into phospholipid vesicles.通过使用掺入磷脂囊泡中的纯化病毒和细胞抗原引发抗水泡性口炎病毒细胞毒性T淋巴细胞。
Infect Immun. 1981 May;32(2):513-7. doi: 10.1128/iai.32.2.513-517.1981.
4
Antigen-liposome modification of target cells as a method to alter their susceptibility to lysis by cytotoxic T lymphocytes.将抗原脂质体修饰靶细胞作为一种改变其对细胞毒性T淋巴细胞裂解敏感性的方法。
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6105-8. doi: 10.1073/pnas.77.10.6105.
5
Dissociation of H-2 recognition by antibody and cytotoxic T cells of a cloned murine leukemia cell line.克隆的小鼠白血病细胞系的抗体和细胞毒性T细胞对H-2识别的解离
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Proc Natl Acad Sci U S A. 1978 Feb;75(2):970-4. doi: 10.1073/pnas.75.2.970.

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Lymphocyte reactivity to serologically undetected components of the major histocompatibility complex.淋巴细胞对主要组织相容性复合体血清学未检测到成分的反应性。
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T-lymphocytes response to Friend virus-induced tumour cell lines in mice of strains congenic at H--2.H-2基因座同基因小鼠中T淋巴细胞对Friend病毒诱导的肿瘤细胞系的反应。
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In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.小鼠对雄性特异性（H-Y）抗原的体外细胞介导免疫反应。
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