骨髓瘤肿瘤与细胞毒性胸腺来源淋巴细胞的反应性周期性丧失。
Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes.
作者信息
Russell J H, Hale A H, Ginns L C, Eisen H N
出版信息
Proc Natl Acad Sci U S A. 1978 Jan;75(1):441-5. doi: 10.1073/pnas.75.1.441.
Abstract
During each transplantation passage of a line of mouse myeloma tumor MOPC-315 through syngeneic (BALB/c) hosts, the tumor cells lose reactivity with cytotoxic thymus-derived lymphocytes directed against products of the BALB/c major histocompatibility complex (H-2d) and regain reactivity on transfer to fresh hosts. In contrast to this cyclical change, the tumor cells remain uniformly reactive with anti-H-2d alloantisera throughout the transplantation cycle.
摘要
在小鼠骨髓瘤肿瘤细胞系MOPC - 315通过同基因（BALB/c）宿主进行的每次移植传代过程中，肿瘤细胞失去了与针对BALB/c主要组织相容性复合体（H - 2d）产物的细胞毒性胸腺来源淋巴细胞的反应性，并在转移至新宿主时恢复反应性。与这种周期性变化相反，肿瘤细胞在整个移植周期中对抗H - 2d同种抗血清保持一致的反应性。
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