Reagan D R, Pfaller M A, Hollis R J, Wenzel R P
Department of Internal Medicine, James H. Quillen School of Medicine, Johnson City, Tennessee, USA.
Diagn Microbiol Infect Dis. 1995 Apr;21(4):191-4. doi: 10.1016/0732-8893(95)00048-f.
Candida albicans is an increasingly important bloodstream pathogen. We investigated a cluster of bloodstream infections in the neonatal intensive care unit (NICU) to determine whether nosocomial transmission occurred. Subjects included any patient in the NICU who developed clinically significant bloodstream infection with C. albicans from January 1984 to December 1987 (N = 7). Isolates were typed by restriction fragment length polymorphism analysis using a C. albicans-specific DNA probe (27A). Four of the neonates were infected from June to August 1984 (1.4 infections per 100 admissions) (the epidemic period) versus none in the period from January to May 1984, and three in the period from September 1984 to December 1987 (0.12 infections per 100 admissions) (P = .002). Three of the four patients in the epidemic period were infected with identical strains, readily distinguished from epidemiologically unrelated strains from the NICU. We conclude that nosocomial transmission of C. albicans occurred and that neonates in intensive care units may represent one group at increased risk.
白色念珠菌是一种日益重要的血流病原体。我们调查了新生儿重症监护病房（NICU）中的一组血流感染病例，以确定是否发生了医院内传播。研究对象包括1984年1月至1987年12月期间在NICU发生具有临床意义的白色念珠菌血流感染的任何患者（N = 7）。使用白色念珠菌特异性DNA探针（27A）通过限制性片段长度多态性分析对分离株进行分型。1984年6月至8月有4名新生儿感染（每100例入院中有1.4例感染）（流行期），而1984年1月至5月期间无感染病例，1984年9月至1987年12月期间有3例感染（每100例入院中有0.12例感染）（P = .002）。流行期的4名患者中有3名感染了相同菌株，这些菌株很容易与NICU中与流行病学无关的菌株区分开来。我们得出结论，白色念珠菌发生了医院内传播，重症监护病房中的新生儿可能是风险增加的一组人群。
