Carlesimo G A, Sabbadini M, Fadda L, Caltagirone C
Università di Roma Tor Vergata.
Cortex. 1995 Jun;31(2):285-300. doi: 10.1016/s0010-9452(13)80363-2.
This study investigated the hypothesis that memory disordered patients suffer of an exalted forgetting rate from long-term memory within the first few minutes following acquisition. For this purpose, we administered to groups of Alzheimer's (AD), Multi-infarct demented (MID), pure amnesic and age-matched normal controls a test involving immediate and 15-min delayed word-list recall and a modified version of the Huppert and Piercy's procedure (1978) assessing yes/no Recognition for pictures at 90 sec, 10 min, 1 hr and 24 hr delay intervals. Results showed an abnormal immediate/delayed performance decline for the word-list recall in AD and pure amnesic patients. In the same period, however, their Recognition score in the Huppert and Piercy's procedure decayed at normal rate. In the following intervals (1 hr and 24 hr), both groups disclosed abnormal forgetting slopes. Vascular demented patients, by contrast, disclosed fully normal forgetting rates both on the word-list recall and on the Huppert and Piercy's procedure. These findings are discussed in the light of cognitive mechanisms and neuroanatomical structures presumably underlying memory consolidation.
记忆障碍患者在记忆获取后的最初几分钟内，长期记忆的遗忘率会升高。为此，我们对阿尔茨海默病（AD）组、多发梗死性痴呆（MID）组、单纯性遗忘症患者组以及年龄匹配的正常对照组进行了一项测试，该测试包括即时和延迟15分钟的单词列表回忆，以及一种经过修改的Huppert和Piercy程序（1978年），用于评估在90秒、10分钟、1小时和24小时延迟间隔时对图片的是/否识别。结果显示，AD患者和单纯性遗忘症患者在单词列表回忆中的即时/延迟表现出现异常下降。然而，在同一时期，他们在Huppert和Piercy程序中的识别分数以正常速度衰减。在随后的间隔时间（1小时和24小时），两组患者的遗忘斜率均出现异常。相比之下，血管性痴呆患者在单词列表回忆和Huppert和Piercy程序中的遗忘率均完全正常。我们根据可能构成记忆巩固基础的认知机制和神经解剖结构对这些发现进行了讨论。
