Chervin R D, Kraemer H C, Guilleminault C
Stanford Sleep Disorders Clinic, Stanford University, CA, USA.
Electroencephalogr Clin Neurophysiol. 1995 Sep;95(3):147-53. doi: 10.1016/0013-4694(95)00075-a.
The multiple sleep latency test (MSLT) is commonly used as an objective measure of sleepiness. We retrospectively correlated MSLT scores from 147 patients with other information relating to sleepiness, namely demographic information, data from nocturnal polysomnograms (PSGs), and subjective assessments. The only variable that showed a valid and statistically significant correlation with the MSLT score was sleep latency on the PSG. The results were largely similar within subgroups focusing on (1) individuals with the ability to fall asleep on every nap, (2) subjects with abnormally short MSLT scores, (3) nap attempts that were successful, and (4) patients with particular diagnoses. We conclude that the mean sleep latency on the MSLT, in a clinical population, does not correlate well with a number of variables expected to influence sleepiness. While the validated utility of the MSLT in separating patients from normals or in identifying narcolepsy is not disputed, the accuracy of the MSLT as a measure of sleepiness appears to be limited.
多次睡眠潜伏期试验（MSLT）通常被用作衡量嗜睡程度的客观指标。我们回顾性地将147例患者的MSLT评分与其他与嗜睡相关的信息进行了关联分析，这些信息包括人口统计学信息、夜间多导睡眠图（PSG）数据以及主观评估。唯一与MSLT评分呈现有效且具有统计学意义相关性的变量是PSG上的睡眠潜伏期。在关注以下几类人群的亚组中，结果大体相似：（1）每次小睡都能入睡的个体；（2）MSLT评分异常短的受试者；（3）成功的小睡尝试；（4）患有特定诊断疾病的患者。我们得出结论，在临床人群中，MSLT的平均睡眠潜伏期与预期会影响嗜睡程度的多个变量之间的相关性不佳。虽然MSLT在区分患者与正常人或识别发作性睡病方面的有效效用并无争议，但MSLT作为嗜睡程度衡量指标的准确性似乎有限。
