Claydon N, Addy M
Dentistry, Department of Oral and Dental Disease, University of Bristol, England.
J Clin Periodontol. 1995 Jul;22(7):540-2. doi: 10.1111/j.1600-051x.1995.tb00802.x.
Short-term methodologies have been developed to screen chemical agents for plaque inhibitory effects. Most measure inhibition of plaque regrowth over several days. A method was described to study agents over 16-24 h periods, although some difficulties with the index used were reported. The aim of this study was to determine whether more conventional plaque scoring methods could be used. These 2 crossover studies measured plaque regrowth over 24 h in 20 subjects and in response to single brushings with either a chlorhexidine and minus active toothpaste or to a fluoride toothpaste product and water. Significantly less plaque had reformed after brushing with the chlorhexidine toothpaste compared with its control and with the fluoride toothpaste compared with water. 18 subjects participated in both studies and using their data for an interstudy comparison, less plaque developed with the chlorhexidine compared with the fluoride toothpaste. These studies had the advantage that longer-term trials already demonstrated the same differences. This permits one to conclude with some certainty that the 24-h plaque regrowth study design, using conventional measures of plaque accumulation, could be a useful and rapid method of screening potential plaque inhibitory agents and formulations.
已开发出短期方法来筛选具有抑制牙菌斑作用的化学制剂。大多数方法是测量数天内牙菌斑再生长的抑制情况。有人描述了一种在16 - 24小时内研究制剂的方法，不过有人报告称所使用的指标存在一些问题。本研究的目的是确定是否可以使用更传统的牙菌斑评分方法。这两项交叉研究在20名受试者中测量了24小时内的牙菌斑再生长情况，受试者分别单次使用洗必泰牙膏和不含活性成分的牙膏刷牙，或使用含氟牙膏产品和清水刷牙。与对照组相比，使用洗必泰牙膏刷牙后牙菌斑再形成的量显著减少；与用水刷牙相比，使用含氟牙膏刷牙后牙菌斑再形成的量也显著减少。18名受试者参与了这两项研究，利用他们的数据进行研究间比较，结果显示与含氟牙膏相比，使用洗必泰牙膏后形成的牙菌斑更少。这些研究的优势在于长期试验已经证明了相同的差异。这使得人们可以有一定把握地得出结论，即采用传统牙菌斑积聚测量方法的24小时牙菌斑再生长研究设计，可能是一种筛选潜在牙菌斑抑制制剂和配方的有用且快速的方法。
