Kanda T, Oriuchi N, Tateno M, Nakano M, Suzuki T, Murata K, Suga S, Nakao K, Endo K
Second Department of Internal Medicine, Gunma University School of Medicine, Japan.
J Med. 1995;26(1-2):53-64.
Atrial natriuretic peptide (ANP) may be an important factor in myocardial infarction and subsequent congestive heart failure. In the failing heart, ANP is expressed in both the atrium and the ventricle. ANP has now been localized with 125I-labeled monoclonal antibodies (MAbs) in vivo in a rat model of myocardial infarction. Myocardial infarction was produced in 3-month-old Wistar rats by ligating the left anterior coronary artery. Two MAbs to rat alpha-ANP accumulated in the infarcted left ventricles of treated rats to a significantly greater extent (p < 0.01) than in the noninfarcted left ventricles of control rats. However, an irrelevant MAb also accumulated to a significantly greater extent in infarcted myocardium than in control myocardium. Thus, the accumulation of the two MAbs to ANP in infarcted tissue seems to be nonspecific and may be due to increased permeability of the injured myocardium.
心房利钠肽（ANP）可能是心肌梗死及随后发生的充血性心力衰竭中的一个重要因素。在衰竭心脏中，ANP在心房和心室均有表达。目前已利用125I标记的单克隆抗体（MAb）在心肌梗死大鼠模型中对ANP进行了体内定位。通过结扎左冠状动脉前降支在3月龄Wistar大鼠中制造心肌梗死。两种针对大鼠α-ANP的单克隆抗体在治疗大鼠梗死的左心室中的蓄积程度显著高于（p < 0.01）对照大鼠未梗死的左心室。然而，一种无关的单克隆抗体在梗死心肌中的蓄积程度也显著高于对照心肌。因此，两种抗ANP单克隆抗体在梗死组织中的蓄积似乎是非特异性的，可能是由于受损心肌通透性增加所致。
