Reichmann P, Varon E, Günther E, Reinert R R, Lüttiken R, Marton A, Geslin P, Wagner J, Hakenbeck R
Max-Planck Institut für Molekulare Genetik, Berlin, Germany.
J Med Microbiol. 1995 Nov;43(5):377-85. doi: 10.1099/00222615-43-5-377.
Penicillin-resistant Streptococcus pneumoniae strains isolated in different parts of Germany between 1982 and 1992 were compared with penicillin-resistant isolates, mainly of serogroups 6, 9, 14, 19 and 23, from other European countries. The main clones were recognised by their serotypes, antibiotic resistance patterns and penicillin-binding protein properties, and this typing was confirmed by multi-locus enzyme electrophoresis for a sample of 43 selected isolates. Eleven of the 14 resistant German isolates could be assigned to five genotypes isolated also in other countries. These included representatives of two distinct serotype 23F lineages predominant in Spain and France; a cluster of three serotype 6B isolates identical to clones in Spain, France, Finland and Hungary; and a serotype 9V clone of a type prevalent in Spain and now also in France. Serotype 19A clones of the type found in Hungary were not collected in Germany. The data suggest that two 23F lineages, represented by seven isolates from different locations, have become disseminated in Germany. Several resistant types found in the former West Germany resembled those found elsewhere in Western Europe whereas those from East Germany were distinct or, in one case, resembled a clone from Hungary. These data may reflect pre-unification travel patterns.
对1982年至1992年间在德国不同地区分离出的耐青霉素肺炎链球菌菌株与来自其他欧洲国家的耐青霉素分离株（主要是血清群6、9、14、19和23）进行了比较。主要克隆通过其血清型、抗生素耐药模式和青霉素结合蛋白特性来识别，并且通过多位点酶电泳对43株选定分离株的样本进行了确认。14株德国耐药分离株中的11株可归为在其他国家也分离出的5种基因型。这些包括在西班牙和法国占主导地位的两个不同血清型23F谱系的代表；一组3株血清型6B分离株，与西班牙、法国、芬兰和匈牙利的克隆相同；以及一种在西班牙流行且现在在法国也流行的血清型9V克隆。在匈牙利发现的血清型19A克隆在德国未收集到。数据表明，由来自不同地点的7株分离株代表的两个血清型23F谱系已在德国传播。在前西德发现的几种耐药类型与在西欧其他地方发现的相似，而来自东德的耐药类型则不同，或者在一个案例中与来自匈牙利的克隆相似。这些数据可能反映了统一前的旅行模式。
